Inhaled corticosteroids for asthma: impact of practice level device switching on asthma control
© Thomas et al; licensee BioMed Central Ltd. 2009
Received: 31 January 2008
Accepted: 02 January 2009
Published: 02 January 2009
As more inhaled corticosteroid (ICS) devices become available, there may be pressure for health-care providers to switch patients with asthma to cheaper inhaler devices. Our objective was to evaluate impact on asthma control of inhaler device switching without an accompanying consultation in general practice.
This 2-year retrospective matched cohort study used the UK General Practice Research Database to identify practices where ICS devices were changed without a consultation for ≥5 patients within 3 months. Patients 6–65 years of age from these practices whose ICS device was switched were individually matched with patients using the same ICS device who were not switched. Asthma control over 12 months after the switch was assessed using a composite measure including short-acting β-agonist and oral corticosteroid use, hospitalizations, and subsequent changes to therapy.
A total of 824 patients from 55 practices had a device switch and could be matched. Over half (53%) of device switches were from dry powder to metered-dose inhalers. Fewer patients in switched than matched cohort experienced successful treatment based on the composite measure (20% vs. 34%) and more experienced unsuccessful treatment (51% vs. 38%). After adjusting for possible baseline confounding factors, the odds ratio for treatment success in the switched cohort compared with controls was 0.29 (95% confidence interval [CI], 0.19 to 0.44; p < 0.001) and for unsuccessful treatment was 1.92 (95% CI, 1.47 to 2.56; p < 0.001).
Switching ICS devices without a consultation was associated with worsened asthma control and is therefore inadvisable.
Much of the costs of asthma are associated with suboptimally controlled disease [1–6]. By one estimate, based on an analysis of several studies, one third of the direct medical costs and three quarters of the total costs of asthma can be attributed to uncontrolled disease . For patients with persistent asthma, inhaled corticosteroids (ICS) are considered to be the most effective controller medications currently available . A range of different molecules and inhaler devices are marketed, and more are regularly being developed, often resulting in several options for ICS delivery.
Each type of inhaler device has its advantages and disadvantages together with cost , and each requires a different inhalation technique. In a recent review of inhaler devices by Virchow et al (2008), device characteristics were compared. Virchow et al suggested that the choice of inhaler may be one reason why asthma remains poorly controlled . Patient training for each device and regular checking of inhalation technique are, therefore, considered to be essential for optimal treatment delivery [8, 10–12]. In fact, many believe, and asthma management guidelines reinforce, that an inhaler should not be prescribed without confirming that the patient knows how to use the device [11, 13].
Prescription cost-containment measures are increasing in many countries and, as more devices become available, there may be pressure to switch patients to a cheaper inhaler device . Indeed, in some countries, such a substitution is mandated by current regulations, and patients who do not accept the substitution have to pay the difference in cost. However, acquisition cost savings from a substitution could be offset by costs related to deterioration in asthma control if the patient is unable or unwilling to use the inhaler device properly.
The purpose of this retrospective database analysis was to evaluate the impact on asthma control of inhaler device switching without an accompanying consultation in general practice in the United Kingdom (UK). Our hypothesis was that, for patients with asthma, switching inhaler device without a consultation is associated with worsened clinical outcomes.
This 2-year retrospective matched cohort study included a baseline period of 1 year before the date of ICS device switch (index date) and an outcome period of 1 year after the index date. Patient data were drawn from 1990–2004 records in the General Practice Research Database (GPRD), a large computerized database of anonymized longitudinal medical records from primary care in the Uk . The years of the switch and matched cohort analyzed in this study are 1992 to 2003. This database includes information for over 13 million patients, including 3.4 million active patients for whom data are currently being gathered. Reports for each patient include demographic data and event history, including date and type of event with a description of the event and the corresponding code. Information about the reason for a switch in device is not recorded. Ethical approval was received from the GPRD Scientific and Ethical Advisory Committee (Protocol 706R, 26.4.05).
Patients eligible for inclusion in this analysis were receiving ICS, were 6–65 years of age on the index date, and had a recorded diagnosis of asthma and no record of chronic obstructive pulmonary disease (COPD). We used the GPRD to identify primary care practices where ICS inhaler devices were switched without an accompanying consultation on the same day for five or more patients within a 3-month period. Patients had to be registered at the practice for at least 1 year before and 1 year after the index date. We included switches to inhaler devices that require training to use, namely, from a dry powder inhaler to a metered-dose inhaler, another brand of dry powder inhaler, or a breath-actuated inhaler or from a breath-actuated to a metered-dose inhaler or another brand of breath-actuated inhaler. Patients changed to a device recorded as 'generic' were excluded.
Each patient included in the analysis was individually matched to another patient (from any practice) who was receiving the same ICS device on the index date and met the following six criteria: same sex, age within 5 years, same smoking status, match on presence or absence of rhinitis history, and, during the prior year, same number of oral corticosteroid prescriptions and hospitalizations for asthma.
Definition of asthma control – a composite measure – over 12 months
Assessment of Asthma Control*
Criterion for the Composite Measure
Partially Successful Treatment
(≥ 1 Criterion)
Mean SABA dose
0.5 to ≤2 doses/day
Oral corticosteroid use/yr
Other data recorded for each patient included assigned socioeconomic status of the primary care practice and other respiratory or confounding diagnoses. The daily dose of ICS was calculated from the prescribing instructions on the first available prescription after the index date.
Baseline characteristics of switched and matched control patients were compared using t and χ2 tests as appropriate. Median intended ICS dose, daily short-acting β-agonist dose, and asthma consultation pattern during the baseline year were compared for the two cohorts using the Mann-Whitney U test. For comparison of change between year 1 and year 2, the paired t test (mean changes in short-acting β-agonist use and asthma consultations) and χ2 test (change or not in ICS dose or device from year 1 to year 2) were used.
For comparisons of the primary outcome measure, in addition to the unadjusted analyses, we used logistic regression to correct for potential baseline confounders. Binary regression models were constructed using as the three outcome variables 1) successful vs. partially successful/unsuccessful treatment, 2) unsuccessful treatment vs. successful/partially successful treatment, and 3) subsequent change in ICS device or dose and, as explanatory variables, cohort membership plus possible confounding factors. Possible baseline confounders entered into the model included 1) short-acting β-agonist use (average daily use categorized as none, ≤0.5 doses/day, >0.5–2 doses/day, >2 doses/day); 2) asthma consultation rate (categorized as: none, 1, 2, ≥3); 3) socioeconomic status (in quintiles); and 4) prescribed ICS dose at switch (in sensitivity analysis as incomplete data due to some patients receiving vague prescribing instructions, categorized as ≤400 μg/day, 401–800 μg/day, 801–2000 μg/day, >2000 μg/day).
Types of inhaled corticosteroid (ICS) device switch for 824 patients whose device was switched without an accompanying clinical visit or consultation
Type of ICS device switch
No. (%) of patients
(n = 824)
Dry powder to metered-dose inhaler
Dry powder to dry powder inhaler (different brand)
Dry powder to breath-actuated inhaler
Breath-actuated to metered-dose inhaler
Breath-actuated to breath-actuated inhaler (different brand)
Baseline and demographic characteristics of the two study cohorts: patients whose inhaled corticosteroid (ICS) device was switched (switched cohort) and the matched patients whose ICS device was not switched (control cohort)
(n = 824)
(n = 824)
p Value For Comparison
Female, n (%)
Age* in yrs
Smoking status,* n (%)
Recorded rhinitis history,* n (%)
Oral corticosteroid courses/yr,* n (%)
Hospitalized for asthma,* n (%)
Socioeconomic quintile, n (%)
SABA daily dose, † median (IQR)
Asthma consultation rate, n (%)
Recorded gastroesophageal disease, n (%)
Recorded cardiovascular disease, n (%)
Daily dose of ICS on index day, ‡ median (IQR)
400 μg (400–800)
400 μg (400–800)
The median intended dose of ICS at the index date was similar for the two cohorts (see Table 3). Data for 601 of 824 patients (73%) in each cohort were used for these calculations; it was not possible to quantify the daily dose for the other 223 patients (27%) in each cohort because the instruction 'as directed' was recorded for their ICS prescriptions. Table 3 highlights that there were some differences (p < 0.05) between cohorts at baseline.
Impact of ICS inhaler device switch: the likelihood of asthma control among switched vs. control patients during the year after the switch
Logistic Regression Analysis*
OR (95% CI)
OR (95% CI)
Subsequent change in ICS device
The likelihood of unsuccessful treatment among switched patients was almost double that for control patients (see Table 4). Other variables predictive of unsuccessful treatment were a greater use of short-acting β-agonist and more asthma consultations at baseline. Including the ICS dose in the model made no substantial difference (OR, 1.93; 95% CI, 1.46 to 2.55; p < 0.001).
Patients in the switched cohort were also more likely than those in the control cohort to experience a subsequent change in ICS device or dose in year 2 (see Table 4). Other variables predictive of ICS change were short-acting β-agonist use, socioeconomic status, and rate of asthma consultation at baseline. Results were not substantially different when the ICS dose was included in the analysis (OR, 1.89; 95% CI, 1.48 to 2.40; p < 0.001). Subsequent changes in ICS device or dose during year 2 were recorded for 273 patients (33.1%) in the switched cohort and 183 patients (22.2%) in the control cohort (p < 0.001).
Impact of ICS inhaler device switch: outcome measures for switched vs. control patients during the year after the switch
(n = 824)
(n = 824)
p Value For Comparison
Oral corticosteroid courses/yr, n (%)
Hospitalized for asthma, n (%)
SABA daily dose,* median (IQR)
Asthma consultation rate, n (%)
Most patients did not require a course of oral corticosteroids during the outcome year, and there were no significant differences between patient groups in the use of oral corticosteroids during this time (Table 5) or in the change in use from baseline. Similarly, there was no significant difference in asthma consultation rate between patients in switched and matched cohorts. Between year 1 and year 2, consultation rates fell slightly by a mean of 0.09 (SD, 1.33) in the switched cohort and by 0.35 (SD, 1.59) in the matched cohort. Thus, as compared with the baseline period, the switched cohort had 0.26 more asthma consultations in the outcome period than the matched cohort (95% CI, 0.11 to 0.40; p < 0.001).
There were very few hospitalizations for asthma during the study. Moreover, there was no significant difference between cohorts in admissions for possible asthma (Table 5) or in the change from baseline to outcome periods in admissions for possible asthma.
Switches in ICS device without clinical visit or consultation were associated with worsened asthma control in this retrospective analysis of a large UK general practice database. Patients whose ICS device was switched were significantly less likely to experience successful asthma treatment and significantly more likely to experience unsuccessful treatment than matched controls whose ICS device had not been switched. When possible baseline confounding factors were incorporated into the analysis, there was an even stronger association of device switch with lack of treatment success: patients with switched ICS device had less than one third the chance of successful treatment and were almost twice as likely to experience unsuccessful treatment or another change in ICS device compared with matched controls.
Use of short-acting β-agonist, a marker for asthma morbidity , increased significantly in the year after switching among patients in the switched cohort relative to controls. The number of hospitalizations for asthma and the number of oral corticosteroid prescriptions were, however, similar in the two cohorts during year 2.
We were able to identify over 100,000 individuals in the database who had undergone a switch in ICS device, and from these numbers were able to identify 55 practices where five or more patients had been switched in a 3-month period without a consultation, confirming our clinical impression that switching of ICS devices without a consultation is not an uncommon occurrence. While it is possible that some consultations occurred but were not recorded, given the multiple switching in these practices it is unlikely that the cases of switch without consultation are falsely identified. ICS device switching is typically implemented as a cost-saving measure. Indeed, in this study, the most common type of switch was from a dry powder inhaler to a metered-dose inhaler, often the cheapest inhaler device. Our study results would suggest, however, that the potential for worsened asthma control, and subsequent associated costs, may outweigh any acquisition cost savings from the switch.
Worsening asthma control after ICS device switching without a consultation could occur because of inadequate dosing secondary to poor technique or because of reduced patient adherence to therapy. Correct inhalation technique is necessary for attaining the full benefits of ICS. However, inhaler devices are difficult to use, especially the metered-dose inhalers, which typically require the most patient instruction on their use [17, 18]. Moreover, patient education and involvement in treatment decisions can improve adherence to therapy [18–20]; thus, it is possible that, without a clinical consultation, adherence was reduced in the switched cohort and asthma control worsened.
There are no other studies, to our knowledge, evaluating the switching of inhaler devices without a consultation. Surveys of the attitudes of health-care professionals and patients about the interchangeability of dry powder inhalers have consistently reported a generally negative attitude about switching dry powder inhalers without input from patient and physician [20–22].
This retrospective matched cohort study drew on data from a large clinical database and as such is limited by the completeness and accuracy of that database . The GPRD is a very large primary care database that is managed with regular quality control and is considered to be valid for respiratory epidemiological research [15, 24]. In theory, however, findings of statistical significance, but not necessarily clinical significance, can emerge from the evaluation of large data sets . We limited our study population to 824 patients who could be individually matched to control patients using quite restrictive criteria. The parameters that were different at baseline for the two cohorts (short-acting β-agonist use, asthma consultations, and socioeconomic status) were included as factors in the regression model.
We chose a composite measure of asthma control to assess the impact of device switching because multiple outcome measures are the best means of determining effectiveness of asthma therapy . The composite measures incorporated several measures of asthma morbidity, including daily short-acting β-agonist dose, change in asthma controller therapy, oral corticosteroid use, and hospitalization for asthma. Inclusion of lung function tests would have been impractical for this kind of study, as lung function tests are often not performed in primary care and are limited in interpretation by ceiling effects. The inclusion of OCS courses and hospitalizations means that a measure of severity was used to match patients, and surrogate measures of severity were entered into the regression model to reduce confounding.
There are a number of possible future studies given the findings of this analysis. The impact of age (child compared with adult) and long acting beta agonists are two possible sub-group analyses. However, care would need to be taken not to decrease the size of the cohort such that the power of the study becomes too weak to make conclusions from the findings.
In conclusion, switching of ICS inhaler devices without a consultation is most commonly used for substitution of a cheaper metered-dose inhaler in place of a dry powder inhaler. Switching ICS inhaler devices without a consultation was associated with worsened asthma control. Therefore, the possible costs of adverse effects on asthma control should be weighed against savings in acquisition costs before instituting mass switching of ICS inhaler devices. Switching ICS inhaler devices without a face-to-face evaluation and consultation is inadvisable.
chronic obstructive pulmonary disease
General Practice Research Database
Writing support was provided by Elizabeth V. Hillyer with financial support from an unrestricted grant from GlaxoSmithKline. Funding for the access to the GPRD data was provided by an unrestricted grant from Schering-Plough, and funding for this analysis of the dataset, as well as writing support, was provided by an unrestricted grant from GlaxoSmithKline
- Herjavecz I, Nagy GB, Gyurkovits K, Magyar P, Dobos K, Nagy L, Alemao E, Ben-Joseph R: Cost, morbidity, and control of asthma in Hungary: The Hunair Study. J Asthma. 2003, 40: 673-681. 10.1081/JAS-120021100.View ArticlePubMedGoogle Scholar
- Barnes PJ, Jonsson B, Klim JB: The costs of asthma. Eur Respir J. 1996, 9: 636-642. 10.1183/09031936.96.09040636.View ArticlePubMedGoogle Scholar
- Bousquet J, Bousquet PJ, Godard P, Daures JP: The public health implications of asthma. Bull World Health Organ. 2005, 83: 548-554.PubMedPubMed CentralGoogle Scholar
- Bootman JL, Crown WH, Luskin AT: Clinical and economic effects of suboptimally controlled asthma. Manag Care Interface. 2004, 17: 31-36.PubMedGoogle Scholar
- Accordini S, Bugiani M, Arossa W, Gerzeli S, Marinoni A, Olivieri M, Pirina P, Carrozzi L, Dallari R, De Togni A, de Marco R: Poor control increases the economic cost of asthma. A multicentre population-based study. Int Arch Allergy Immunol. 2006, 141: 189-198. 10.1159/000094898.View ArticlePubMedGoogle Scholar
- Hoskins G, McCowan C, Neville RG, Thomas GE, Smith B, Silverman S: Risk factors and costs associated with an asthma attack. Thorax. 2000, 55: 19-24. 10.1136/thorax.55.1.19.View ArticlePubMedPubMed CentralGoogle Scholar
- Global Strategy for Asthma Management and Prevention, Global Initiative for Asthma (GINA). 2006, [http://www.ginasthma.org]
- Dolovich MB, Ahrens RC, Hess DR, Anderson P, Dhand R, Rau JL, Smaldone GC, Guyatt G, American College of Chest Physicians; American College of Asthma, Allergy, and Immunology: Device selection and outcomes of aerosol therapy: Evidence-based guidelines: American College of Chest Physicians/American College of Asthma, Allergy, and Immunology. Chest. 2005, 127: 335-371. 10.1378/chest.127.1.335.View ArticlePubMedGoogle Scholar
- Virchow JC, Crompton GK, Dal Negro R, Pedersen S, Magnan A, Seidenberg J, Barnes PJ: Importance of inhaler devices in the management of airway disease. Respiratory Medicine. 2008, 102: 10-19. 10.1016/j.rmed.2007.07.031.View ArticlePubMedGoogle Scholar
- Crompton GK, Barnes PJ, Broeders M, Corrigan C, Corbetta L, Dekhuijzen R, Dubus JC, Magnan A, Massone F, Sanchis J, Viejo JL, Voshaar T, Aerosol Drug Management Improvement Team: The need to improve inhalation technique in Europe: a report from the Aerosol Drug Management Improvement Team. Respir Med. 2006, 100: 1479-1494. 10.1016/j.rmed.2006.01.008.View ArticlePubMedGoogle Scholar
- Scottish Intercollegiate Guidelines Network: British Guideline on the Management of Asthma. [http://www.sign.ac.uk/methodology/index.html]
- Brocklebank D, Ram F, Wright J, Barry P, Cates C, Davies L, Douglas G, Muers M, Smith D, White J: Comparison of the effectiveness of inhaler devices in asthma and chronic obstructive airways disease: a systematic review of the literature. Health Technol Assess. 2001, 5: 1-149.View ArticlePubMedGoogle Scholar
- Rees J: Methods of delivering drugs. BMJ. 2005, 331: 504-506. 10.1136/bmj.331.7515.504.View ArticlePubMedPubMed CentralGoogle Scholar
- Price D, Summers M, Zanen P: Could interchangeable use of dry powder inhalers affect patients?. Int J Clin Pract Suppl. 2005, 3-6. 10.1111/j.1368-504X.2005.00720.x.Google Scholar
- The General Practice Research Database. [http://www.gprd.com/home/]
- Naureckas ET, Dukic V, Bao X, Rathouz P: Short-acting beta-agonist prescription fills as a marker for asthma morbidity. Chest. 2005, 128: 602-608. 10.1378/chest.128.2.602.View ArticlePubMedGoogle Scholar
- Geller DE: Comparing clinical features of the nebulizer, metered-dose inhaler, and dry powder inhaler. Respir Care. 2005, 50: 1313-1321.PubMedGoogle Scholar
- Cochrane MG, Bala MV, Downs KE, Mauskopf J, Ben-Joseph RH: Inhaled corticosteroids for asthma therapy: patient compliance, devices, and inhalation technique. Chest. 2000, 117: 542-550. 10.1378/chest.117.2.542.View ArticlePubMedGoogle Scholar
- Williams LK, Pladevall M, Xi H, Peterson EL, Joseph C, Lafata JE, Ownby DR, Johnson CC: Relationship between adherence to inhaled corticosteroids and poor outcomes among adults with asthma. J Allergy Clin Immunol. 2004, 114: 1288-1293. 10.1016/j.jaci.2004.09.028.View ArticlePubMedGoogle Scholar
- Price D: Do healthcare professionals think that dry powder inhalers can be used interchangeably?. Int J Clin Pract Suppl. 2005, 26-29. 10.1111/j.1368-504X.2005.00724.x.Google Scholar
- Williams AE, Chrystyn H: Survey of pharmacists' attitudes towards interchangeable use of dry powder inhalers. Pharm World Sci. 2007, 29: 221-227. 10.1007/s11096-006-9079-6.View ArticlePubMedGoogle Scholar
- Booker R: Do patients think that dry powder inhalers can be used interchangeably?. Int J Clin Pract Suppl. 2005, 30-32. 10.1111/j.1368-504X.2005.00725.x.Google Scholar
- Thomas M, Cleland J, Price D: Database studies in asthma pharmacoeconomics: uses, limitations and quality markers. Expert Opin Pharmacother. 2003, 4: 351-358. 10.1517/146565126.96.36.1991.View ArticlePubMedGoogle Scholar
- Hansell A, Hollowell J, Nichols T, McNiece R, Strachan D: Use of the General Practice Research Database (GPRD) for respiratory epidemiology: a comparison with the 4th Morbidity Survey in General Practice (MSGP4). Thorax. 1999, 54: 413-419.View ArticlePubMedPubMed CentralGoogle Scholar
- Barnes NC: Outcome measures in asthma. Thorax. 2000, 55 (Suppl 1): S70-74. 10.1136/thorax.55.suppl_1.S70.View ArticlePubMedPubMed CentralGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2466/9/1/prepub
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