Asthma and allergic disorders

Section edited by Joerg Mattes

This section concerns all aspects of asthma and allergic disorders including, but not limited to: prevention, diagnosis and management, as well as related molecular genetics, and pathophysiology.

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  1. Research article

    Obstructive sleep apnoea accelerates FEV1 decline in asthmatic patients

    Although the prevalence of both obstructive sleep apnoea (OSA) and asthma are both increasing, little is known about the impact of OSA on the natural history of lung function in asthmatic patients.

    Tsai-Yu Wang, Yu-Lun Lo, Shu-Min Lin, Chien-Da Huang, Fu-Tasi Chung, Horng-Chyuan Lin, Chun-Hua Wang and Han-Pin Kuo

    BMC Pulmonary Medicine 2017 17:55

    Published on: 21 March 2017

  2. Study protocol

    Effectiveness of pulmonary rehabilitation for patients with asthma: study protocol of a randomized controlled trial (EPRA)

    Asthma patients are enrolled in multimodal pulmonary rehabilitation (PR) programs. However, available data for the effectiveness of PR in asthma are sparse. Therefore, the primary aim of this randomized contro...

    Konrad Schultz, Hildegard Seidl, Danijel Jelusic, Rupert Wagner, Michael Wittmann, Hermann Faller, Dennis Nowak and Michael Schuler

    BMC Pulmonary Medicine 2017 17:49

    Published on: 9 March 2017

  3. Research article

    Predictors of correct technique in patients using pressurized metered dose inhalers

    Correct inhaler technique is recommended by guidelines for optimum asthma care. The objective of the study is to determine real life predictors of correct pressurized metered dose inhaler (pMDI) technique in A...

    Kyra Bartolo, Martin Balzan, Emma Louise Schembri, Rachelle Asciak, Darlene Mercieca Balbi, Michael Pace Bardon and Stephen Montefort

    BMC Pulmonary Medicine 2017 17:47

    Published on: 28 February 2017

  4. Research article

    Persistent asthma phenotype related with late-onset, high atopy, and low socioeconomic status in school-aged Korean children

    Treatment guidelines for asthma have been established based on asthma severity; there are limitations in the identification of underlying pathophysiology and prediction of prognosis in heterogeneous phenotypes...

    Eun Lee, Si Hyeon Lee, Ji-Won Kwon, Young-Ho Kim, Jisun Yoon, Hyun-Ju Cho, Song-I Yang, Young-Ho Jung, Hyung Young Kim, Ju-Hee Seo, Hyo Bin Kim, So Yeon Lee, Ho-Jang Kwon and Soo-Jong Hong

    BMC Pulmonary Medicine 2017 17:45

    Published on: 23 February 2017

  5. Research article

    Effect of inhaled corticosteroid particle size on asthma efficacy and safety outcomes: a systematic literature review and meta-analysis

    Inhaled corticosteroids (ICS) are the primary treatment for persistent asthma. Currently available ICS have differing particle size due to both formulation and propellant, and it has been postulated that this ...

    Céline El Baou, Rachael L. Di Santostefano, Rafael Alfonso-Cristancho, Elizabeth A Suarez, David Stempel, Mark L Everard and Neil Barnes

    BMC Pulmonary Medicine 2017 17:31

    Published on: 7 February 2017

  6. Research article

    Epigenetic modifying enzyme expression in asthmatic airway epithelial cells and fibroblasts

    Recognition of the airway epithelium as a central mediator in the pathogenesis of asthma has necessitated greater understanding of the aberrant cellular mechanisms of the epithelium in asthma. The architecture...

    Dorota Stefanowicz, Jari Ullah, Kevin Lee, Furquan Shaheen, Ekiomoado Olumese, Nick Fishbane, Hyun-Kyoung Koo, Teal S. Hallstrand, Darryl A. Knight and Tillie-Louise Hackett

    BMC Pulmonary Medicine 2017 17:24

    Published on: 31 January 2017

  7. Research article

    What patients really think about asthma guidelines: barriers to guideline implementation from the patients’ perspective

    Treatment of asthma does not always comply with asthma guidelines (AG). This may be rooted in direct or indirect resistance on the doctors’ and/or patients’ side or be caused by the healthcare system. To asses...

    H. Lingner, B. Burger, P. Kardos, C. P. Criée, H. Worth and E. Hummers-Pradier

    BMC Pulmonary Medicine 2017 17:13

    Published on: 11 January 2017

  8. Research article

    High strength extrafine pMDI beclometasone/formoterol (200/6 μg) is effective in asthma patients not adequately controlled on medium-high dose of inhaled corticosteroids

    A high strength of beclomethasone/formoterol fumarate (BDP/FF) in a pressurised metered dose inhaler (pMDI), which contains extrafine BDP (200 μg/actuation) and FF (6 μg/actuation) has been developed to treat tho...

    Pierluigi Paggiaro, Massimo Corradi, Manuela Latorre, Helene Raptis, Annamaria Muraro, Christian Gessner, Zenon Siergiejko, Mario Scuri and Stefano Petruzzelli

    BMC Pulmonary Medicine 2016 16:180

    Published on: 9 December 2016

  9. Research article

    Can severe asthmatic patients achieve asthma control? A systematic approach in patients with difficult to control asthma followed in a specialized clinic

    Despite advances in asthma treatment, severe asthma (SA) still results in high morbidity and use of health resources. Our hypothesis was that SA patients would achieve adequate control with a systematic protoc...

    Rodrigo Athanazio, Regina Carvalho-Pinto, Frederico Leon Arrabal Fernandes, Samia Rached, Klaus Rabe, Alberto Cukier and Rafael Stelmach

    BMC Pulmonary Medicine 2016 16:153

    Published on: 16 November 2016

  10. Research article

    Impact of occupational exposures on exacerbation of asthma: a population-based asthma cohort study

    Asthma is a prevalent chronic disease and occupation contributes to approximately 15 % of cases among adults. However, there are still few studies on risk factors for work-exacerbated asthma. The current study...

    Jeong-Lim Kim, Paul K. Henneberger, Susanna Lohman, Anna-Carin Olin, Anna Dahlman-Höglund, Eva Andersson, Kjell Torén and Mathias Holm

    BMC Pulmonary Medicine 2016 16:148

    Published on: 15 November 2016

  11. Research article

    Drop-out rate among patients treated with omalizumab for severe asthma: Literature review and real-life experience

    In patients with asthma, particularly severe asthma, poor adherence to inhaled drugs negatively affects the achievement of disease control. A better adherence rate is expected in the case of injected drugs, su...

    M. Caminati, G. Senna, G. Stefanizzi, R. Bellamoli, S. Longhi, F. Chieco-Bianchi, G. Guarnieri, S. Tognella, M. Olivieri, C. Micheletto, G. Festi, E. Bertocco, M. Mazza, A. Rossi and A. Vianello

    BMC Pulmonary Medicine 2016 16:128

    Published on: 25 August 2016

  12. Research article

    Changes in symptoms of asthma and rhinitis by sensitization status over ten years in a cohort of young Chilean adults

    We investigated the net changes in prevalence of symptoms of asthma and rhinitis over 10 years in a cohort of young by baseline sensitization status.

    Vanessa Garcia-Larsen, James F. Potts, Stefano Del Giacco, Patricia Bustos, Patricia V. Diaz, Hugo Amigo, Manuel Oyarzun and Roberto J. Rona

    BMC Pulmonary Medicine 2016 16:116

    Published on: 8 August 2016

  13. Research article

    A case–control study of innate immunity pathway gene polymorphisms in Puerto Ricans reveals association of toll-like receptor 2 +596 variant with asthma

    For many years, African Dust Storms (ADE) has been thought to be associated with high prevalence of asthma in Puerto Rico (PR). Endotoxins (ENX) have been associated with ADE particulate matter (PM) and are kn...

    Mario G. Ortiz-Martínez, Orquídea Frías-Belén, Sylvette Nazario-Jiménez, María López-Quintero, Rosa I. Rodríguez-Cotto and Braulio D. Jiménez-Vélez

    BMC Pulmonary Medicine 2016 16:112

    Published on: 5 August 2016

  14. Research article

    Value of peripheral blood eosinophil markers to predict severity of asthma

    Asthma represents a significant clinical and economic burden to the US healthcare system. Along with other clinical manifestations of the disease, elevated sputum and blood eosinophil levels are observed in pa...

    Julian Casciano, Jerry A. Krishnan, Mary Buatti Small, Philip O. Buck, Gokul Gopalan, Chenghui Li, Robert Kemp and Zenobia Dotiwala

    BMC Pulmonary Medicine 2016 16:109

    Published on: 29 July 2016

  15. Research article

    Burden of asthma with elevated blood eosinophil levels

    Asthma is a common chronic condition with an economic burden of almost $56 billion annually in the US. Biologic markers like blood eosinophils, that help predict the risk of exacerbation could help guide more ...

    Julian Casciano, Jerry A. Krishnan, Mary Buatti Small, Philip O. Buck, Gokul Gopalan, Chenghui Li, Robert Kemp and Zenobia Dotiwala

    BMC Pulmonary Medicine 2016 16:100

    Published on: 13 July 2016

  16. Research article

    Interactive digital interventions to promote self-management in adults with asthma: systematic review and meta-analysis

    To identify, summarise and synthesise the evidence for using interactive digital interventions to support patient self-management of asthma, and determine their impact.

    Gary McLean, Elizabeth Murray, Rebecca Band, Keith R. Moffat, Peter Hanlon, Anne Bruton, Mike Thomas, Lucy Yardley and Frances S. Mair

    BMC Pulmonary Medicine 2016 16:83

    Published on: 23 May 2016

  17. Research article

    “A year-long, fortnightly, observational survey in three European countries of patients with respiratory allergies induced by house dust mites: Methodology, demographics and clinical characteristics”

    House dust mite (HDM) allergens constitute the leading trigger for the symptoms of persistent respiratory allergies (such as allergic rhinitis and asthma). However, the fluctuating, pernicious nature of the sy...

    Pascal Demoly, Andrea Matucci, Oliviero Rossi and Carmen Vidal

    BMC Pulmonary Medicine 2016 16:85

    Published on: 23 May 2016

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