Infectious, Rare and Idiopathic Pulmonary Diseases

Section edited by Sanjay Chotirmall and Giovanni Sotgiu

This section concerns all aspects of pulmonary infection, rare and idiopathic lung diseases including, but not limited to: prevention, diagnosis and management, as well as related molecular genetics, and pathophysiology.

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  1. Research article

    Analysis of long term CD4+CD25highCD127- T-reg cells kinetics in peripheral blood of lung transplant recipients

    The role of CD4+CD25highCD127 T-reg cells in solid-organ Transplant (Tx) acceptance has been extensively studied. In previous studies on kidney and liver recipients, peripheral T-reg cell counts were associated ...

    Davide Piloni, Monica Morosini, Sara Magni, Alice Balderacchi, Luigia Scudeller, Emanuela Cova, Tiberio Oggionni, Giulia Stella, Carmine Tinelli, Filippo Antonacci, Andrea Maria D’Armini and Federica Meloni

    BMC Pulmonary Medicine 2017 17:102

    Published on: 18 July 2017

  2. Case report

    Monitoring clinical and microbiological evolution of a cystic fibrosis patient over 26 years: experience of a Brazilian CF Centre

    Burkholderia cepacia complex is a group of opportunistic pathogens in cystic fibrosis (CF) patients believed to be associated with poor prognosis and patient-to-patient transmissibilit...

    Cassiana da Costa Ferreira Leite, Tania Wrobel Folescu, Mônica de Cássia Firmida, Renata Wrobel Folescu Cohen, Robson Souza Leão, Flávia Alvim Dutra de Freitas, Rodolpho Mattos Albano, Claudia Henrique da Costa and Elizabeth Andrade Marques

    BMC Pulmonary Medicine 2017 17:100

    Published on: 14 July 2017

  3. Research article

    Bacteraemia and fungaemia in cystic fibrosis patients with febrile pulmonary exacerbation: a prospective observational study

    Bloodstream pathogens can be identified by multiplex PCR (SeptiFast (SF)) or blood culture (BC); whether these pathogens are present in cystic fibrosis (CF) patients during febrile pulmonary exacerbations (FPE...

    Joerg Grosse-Onnebrink, Florian Stehling, Eva Tschiedel, Margarete Olivier, Uwe Mellies, Rene Schmidt, Jan Buer, Peter-Micheal Rath and Joerg Steinmann

    BMC Pulmonary Medicine 2017 17:96

    Published on: 29 June 2017

  4. Case report

    Sarcoidosis as a rare cause for symmetrical giant bullous disease

    Sarcoidosis presents with typical clinic-radiological findings and shows histologically non-caseating granulomas. Pulmonary manifestations of sarcoidosis can be diverse, involving the intrathoracic lymph nodes...

    Wolfgang Jungraithmayr, Elisa Leggeri, Walter Weder and Bart Vrugt

    BMC Pulmonary Medicine 2017 17:88

    Published on: 30 May 2017

  5. Research article

    Evaluation of gene xpert for routine diagnosis of HIV-associated tuberculosis in Nigeria: A prospective cohort study

    Xpert MTB/Rif (Xpert) is described as a game changer in tuberculosis (TB) control. We evaluated the impact of Xpert on diagnosis, time to treatment, and treatment outcome among patients with HIV associated TB ...

    Maxwell Oluwole Akanbi, Chad Achenbach, Babafemi Taiwo, John Idoko, Agatha Ani, Yetunde Isa, Oche Agbaji, Christiana Ukoli, Patrick Akande, Mamoudou Maiga and Robert Leo Murphy

    BMC Pulmonary Medicine 2017 17:87

    Published on: 30 May 2017

  6. Research article

    Chronic hypersensitivity pneumonitis: identification of key prognostic determinants using automated CT analysis

    Chronic hypersensitivity pneumonitis (CHP) has a variable disease course. Computer analysis of CT features was used to identify a subset of CHP patients with an outcome similar to patients with idiopathic pulm...

    Joseph Jacob, Brian J. Bartholmai, Ryoko Egashira, Anne Laure Brun, Srinivasan Rajagopalan, Ronald Karwoski, Maria Kokosi, David M. Hansell and Athol U. Wells

    BMC Pulmonary Medicine 2017 17:81

    Published on: 4 May 2017

  7. Research article

    Prognostic factors in hospitalized community-acquired pneumonia: a retrospective study of a prospective observational cohort

    To date, only few studies have examined the prognostic factors of community-acquired pneumonia (CAP) defined according to the latest criteria, which excludes healthcare-associated pneumonia (HCAP). Therefore, ...

    Akihiro Ito, Tadashi Ishida, Hironobu Tokumasu, Yasuyoshi Washio, Akio Yamazaki, Yuhei Ito and Hiromasa Tachibana

    BMC Pulmonary Medicine 2017 17:78

    Published on: 2 May 2017

  8. Case report

    Invasive pulmonary mucormycosis: rare presentation with pulmonary eosinophilia

    Fungi can cause a variety of infectious diseases, including invasive mycosis and non-invasive mycosis, as well as allergic diseases. The different forms of mycosis usually have been described as mutually exclu...

    Taizou Hirano, Mitsuhiro Yamada, Kei Sato, Koji Murakami, Tokiwa Tamai, Yoshiya Mitsuhashi, Tsutomu Tamada, Hisatoshi Sugiura, Naomi Sato, Ryoko Saito, Junya Tominaga, Akira Watanabe and Masakazu Ichinose

    BMC Pulmonary Medicine 2017 17:76

    Published on: 28 April 2017

  9. Research article

    Latin America validation of FACED score in patients with bronchiectasis: an analysis of six cohorts

    The FACED score is an easy-to-use multidimensional grading system that has demonstrated an excellent prognostic value for mortality in patients with bronchiectasis. A Spanish group developed the score but no m...

    Rodrigo Athanazio, Mônica Corso Pereira, Georgina Gramblicka, Fernando Cavalcanti-Lundgren, Mara Fernandes de Figueiredo, Francisco Arancibia, Samia Rached, David de la Rosa, Luis Máiz-Carro, Rosa Girón, Casilda Olveira, Concepción Prados and Miguel Angel Martinez-Garcia

    BMC Pulmonary Medicine 2017 17:73

    Published on: 26 April 2017

  10. Research article

    Exploratory analysis of the neutrophil to lymphocyte ratio in patients with pulmonary arterial hypertension

    Chronic inflammation emerges as a feature of the pathogenesis of pulmonary arterial hypertension (PAH) in experimental models. Alterations of circulating cell subsets have been observed in patients with PAH. W...

    Lars Harbaum, Kaaja M. Baaske, Marcel Simon, Tim Oqueka, Christoph Sinning, Antonia Glatzel, Nicole Lüneburg, Karsten Sydow, Carsten Bokemeyer and Hans Klose

    BMC Pulmonary Medicine 2017 17:72

    Published on: 26 April 2017

  11. Research article

    Water-pipe smoke condensate increases the internalization of Mycobacterium Bovis of type II alveolar epithelial cells (A549)

    Tuberculosis (TB) is a major global health problem, and there is an association between tobacco smoke and TB. Water pipe smoking has become an increasing problem not only in Middle Eastern countries but also g...

    Esmaeil Mortaz, Shamila D. Alipoor, Masoud Movassaghi, Mohammad Varahram, Jahangir Ghorbani, Gert Folkerts, Johan Garssen and Ian M. Adcock

    BMC Pulmonary Medicine 2017 17:68

    Published on: 21 April 2017

  12. Research article

    Co-colonisation with Aspergillus fumigatus and Pseudomonas aeruginosa is associated with poorer health in cystic fibrosis patients: an Irish registry analysis

    Pulmonary infection is the main cause of death in cystic fibrosis (CF). Aspergillus fumigatus (AF) and Pseudomonas aeruginosa (PA) are the most prevalent fungal and bacterial pathogens isolated from the CF airway...

    Emma Reece, Ricardo Segurado, Abaigeal Jackson, Siobhán McClean, Julie Renwick and Peter Greally

    BMC Pulmonary Medicine 2017 17:70

    Published on: 21 April 2017

  13. Research article

    Impact of lymphocyte differential count > 15% in BALF on the mortality of patients with acute exacerbation of chronic fibrosing idiopathic interstitial pneumonia

    Chronic fibrosing idiopathic interstitial pneumonia (CFIIP) has a potential risk of acute exacerbation (AE). However, the usefulness of cellular analysis of bronchoalveolar lavage fluid (BALF) has never been e...

    Reoto Takei, Machiko Arita, Shogo Kumagai, Yuhei Ito, Maki Noyama, Fumiaki Tokioka and Tadashi Ishida

    BMC Pulmonary Medicine 2017 17:67

    Published on: 20 April 2017

  14. Research article

    Penicillin treatment for patients with Community-Acquired Pneumonia in Denmark: a retrospective cohort study

    Community-acquired pneumonia (CAP) is a severe infection, with high mortality. Antibiotic strategies for CAP differ across Europe.

    Gertrud Baunbæk Egelund, Andreas Vestergaard Jensen, Stine Bang Andersen, Pelle Trier Petersen, Bjarne Ørskov Lindhardt, Christian von Plessen, Gernot Rohde and Pernille Ravn

    BMC Pulmonary Medicine 2017 17:66

    Published on: 20 April 2017

  15. Research article

    Effect of pulmonary arteriovenous malformations on the mechanical properties of the lungs

    Pulmonary arteriovenous malformations (PAVMs) are present in approximately 15–50% individuals with hereditary hemorrhagic telangiectasia (HHT). They may be isolated but more often are multiple. The goal of thi...

    Cécile Rotenberg, Marcel Bonay, Mostafa El Hajjam, Sandra Blivet, Alain Beauchet, Pascal Lacombe and Thierry Chinet

    BMC Pulmonary Medicine 2017 17:64

    Published on: 19 April 2017

  16. Research article

    Healthcare burden of pulmonary hypertension owing to lung disease and/or hypoxia

    Group 3 pulmonary hypertension (PH) encompasses PH owing to lung diseases and/or hypoxia. Treatment patterns, healthcare resource use, and economic burden to US payers of Group 3 PH patients were assessed.

    Gustavo A. Heresi, David M. Platt, Wenyi Wang, Christine H. Divers, Vijay N. Joish, Simon A. Teal and Justin S. Yu

    BMC Pulmonary Medicine 2017 17:58

    Published on: 11 April 2017

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