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  1. Research article

    Effect of inhaled corticosteroid particle size on asthma efficacy and safety outcomes: a systematic literature review and meta-analysis

    Inhaled corticosteroids (ICS) are the primary treatment for persistent asthma. Currently available ICS have differing particle size due to both formulation and propellant, and it has been postulated that this ...

    Céline El Baou, Rachael L. Di Santostefano, Rafael Alfonso-Cristancho, Elizabeth A Suarez, David Stempel, Mark L Everard and Neil Barnes

    BMC Pulmonary Medicine 2017 17:31

    Published on: 7 February 2017

  2. Research article

    Hemosiderin-laden macrophages are an independent factor correlated with pulmonary vascular resistance in idiopathic pulmonary fibrosis: a case control study

    Increases in hemosiderin-laden macrophages (HLM) are reported to be observed in idiopathic pulmonary fibrosis (IPF). According to a recent study, significant correlation between hemosiderin deposition in the l...

    Jun Fukihara, Hiroyuki Taniguchi, Masahiko Ando, Yasuhiro Kondoh, Tomoki Kimura, Kensuke Kataoka, Taiki Furukawa, Takeshi Johkoh, Junya Fukuoka, Koji Sakamoto and Yoshinori Hasegawa

    BMC Pulmonary Medicine 2017 17:30

    Published on: 6 February 2017

  3. Research article

    Early exposure to hyperoxia and mortality in critically ill patients with severe traumatic injuries

    Hyperoxia is common early in the course of resuscitation of critically ill patients. It has been associated with mortality in some, but not all, studies of cardiac arrest patients and other critically ill coho...

    Derek W. Russell, David R. Janz, William L. Emerson, Addison K. May, Gordon R. Bernard, Zhiguo Zhao, Tatsuki Koyama and Lorraine B. Ware

    BMC Pulmonary Medicine 2017 17:29

    Published on: 3 February 2017

  4. Research article

    Development of a respiratory severity score for hospitalized adults in a high HIV-prevalence setting—South Africa, 2010–2011

    Acute lower respiratory tract infections (LRTI) are a frequent cause of hospitalization and mortality in South Africa; however, existing respiratory severity scores may underestimate mortality risk in HIV-infe...

    Alexander J. Millman, Adena Greenbaum, Sibongile Walaza, Adam L. Cohen, Michelle J. Groome, Carrie Reed, Meredith McMorrow, Stefano Tempia, Marietjie Venter, Florette K. Treurnicht, Shabir A. Madhi, Cheryl Cohen and Ebrahim Variava

    BMC Pulmonary Medicine 2017 17:28

    Published on: 2 February 2017

  5. Research article

    Airway wall thickness on HRCT scans decreases with age and increases with smoking

    To investigate if age, gender and smoking are associated with airway wall thickness (AWT) measured by high resolution computed tomography (HRCT) and if higher AWT is associated with lower levels of pulmonary f...

    Eef D. Telenga, Matthijs Oudkerk, Peter M. A. van Ooijen, Rozemarijn Vliegenthart, Nick H. T. ten Hacken, Dirkje S. Postma and Maarten van den Berge

    BMC Pulmonary Medicine 2017 17:27

    Published on: 1 February 2017

  6. Research article

    Immediate salbutamol responsiveness does not predict long-term benefits of indacaterol in patients with chronic obstructive pulmonary disease

    The purpose of this study was to evaluate the correlation between immediate responsiveness with the short-acting β2-agonist salbutamol and effects of treatment with the ultra-long-acting β2-agonist indacaterol in...

    Pierre-Régis Burgel, Vincent Le Gros, Laurent Decuypère, Isabelle Bourdeix, Thierry Perez and Gaëtan Deslée

    BMC Pulmonary Medicine 2017 17:25

    Published on: 31 January 2017

  7. Research article

    Epigenetic modifying enzyme expression in asthmatic airway epithelial cells and fibroblasts

    Recognition of the airway epithelium as a central mediator in the pathogenesis of asthma has necessitated greater understanding of the aberrant cellular mechanisms of the epithelium in asthma. The architecture...

    Dorota Stefanowicz, Jari Ullah, Kevin Lee, Furquan Shaheen, Ekiomoado Olumese, Nick Fishbane, Hyun-Kyoung Koo, Teal S. Hallstrand, Darryl A. Knight and Tillie-Louise Hackett

    BMC Pulmonary Medicine 2017 17:24

    Published on: 31 January 2017

  8. Research article

    Pulmonary oxygen uptake and muscle deoxygenation kinetics during heavy intensity cycling exercise in patients with emphysema and idiopathic pulmonary fibrosis

    Little is known about the mechanistic basis for the exercise intolerance characteristic of patients with respiratory disease; a lack of clearly defined, distinct patient groups limits interpretation of many st...

    Melitta A. McNarry, Nicholas K. Harrison, Tom Withers, Narendra Chinnappa and Michael J. Lewis

    BMC Pulmonary Medicine 2017 17:26

    Published on: 31 January 2017

  9. Study protocol

    Effects of periodontal treatment on exacerbation frequency and lung function in patients with chronic periodontitis: study protocol of a 1-year randomized controlled trial

    Chronic obstructive pulmonary disease (COPD) has been associated with periodontal disease (PD), and periodontal treatment (PT) has been connected to reduction of lung disease exacerbations. Bronchiectasis has ...

    Sergio Romero Santos, Erika Horácio Pinto, Priscila Larcher Longo, Simone Dal Corso, Fernanda Cordoba Lanza, Rafael Stelmach, Samia Zahi Rached, Adriana Lino-dos-Santos-Franco, Marcia Pinto Alves Mayer, Sandra Kalil Bussadori, Kristianne Porta Santos Fernandes, Raquel Agnelli Mesquita-Ferrari and Anna Carolina Ratto Tempestini Horliana

    BMC Pulmonary Medicine 2017 17:23

    Published on: 23 January 2017

    The Erratum to this article has been published in BMC Pulmonary Medicine 2017 17:51

  10. Study protocol

    A prospective pilot study of home monitoring in adults with cystic fibrosis (HOME-CF): protocol for a randomised controlled trial

    Home monitoring has the potential to detect early pulmonary exacerbations in people with cystic fibrosis (CF), with consequent improvements in health outcomes and healthcare associated costs. This study aims t...

    Jocelyn Choyce, Karen L. Shaw, Alice J. Sitch, Hema Mistry, Joanna L. Whitehouse and Edward F. Nash

    BMC Pulmonary Medicine 2017 17:22

    Published on: 23 January 2017

  11. Research article

    Can healthcare utilization data reliably capture cases of chronic respiratory diseases? a cross-sectional investigation in Italy

    Healthcare utilization data are increasingly used for chronic disease surveillance. Nevertheless, no standard criteria for estimating prevalence of high-impact diseases, such as chronic obstructive pulmonary d...

    A Biffi, R Comoretto, A Arfè, L Scotti, L Merlino, A Vaghi, A Pesci, R de Marco and G Corrao

    BMC Pulmonary Medicine 2017 17:20

    Published on: 19 January 2017

  12. Research article

    Cystic fibrosis physicians’ perspectives on the timing of referral for lung transplant evaluation: a survey of physicians in the United States

    Prior studies reveal that a significant proportion of patients with cystic fibrosis (CF) and advanced lung disease are not referred for lung transplant (LTx) evaluation. We sought to assess expert CF physician...

    Kathleen J. Ramos, Ranjani Somayaji, Erika D. Lease, Christopher H. Goss and Moira L. Aitken

    BMC Pulmonary Medicine 2017 17:21

    Published on: 19 January 2017

  13. Research article

    A novel reflex cough testing device

    The reflex cough test is useful for detecting silent aspiration, a risk factor for aspiration pneumonia. However, assessing the risk of aspiration pneumonia requires measuring not only the cough reflex but als...

    Kazunori Fujiwara, Katsuyuki Kawamoto, Yoko Shimizu, Takahiro Fukuhara, Satoshi Koyama, Hideyuki Kataoka, Hiroya Kitano and Hiromi Takeuchi

    BMC Pulmonary Medicine 2017 17:19

    Published on: 18 January 2017

  14. Research article

    A follow-up study of airway symptoms and lung function among residents and workers 5.5 years after an oil tank explosion

    Assess if people who lived or worked in an area polluted after an oil tank explosion had persistent respiratory health impairment as compared to a non-exposed population 5.5 years after the event.

    Jens-Tore Granslo, Magne Bråtveit, Bjørg Eli Hollund, Stein Håkon Låstad Lygre, Cecilie Svanes and Bente Elisabeth Moen

    BMC Pulmonary Medicine 2017 17:18

    Published on: 17 January 2017

  15. Case report

    Successful outcome following pneumonectomy in a teenage boy with cystic fibrosis: a case report

    Cystic fibrosis lung disease is generally a diffuse process however rarely one lung may become particularly damaged through chronic collapse and consolidation resulting in end-stage bronchiectasis with relativ...

    Zheyi Liew, Santosh Mallikarjuna, Asif Hasan, F. Kate Gould, Su Bunn, Matthew F. Thomas, Jim L. Lordan, Christopher O’Brien and Malcolm Brodlie

    BMC Pulmonary Medicine 2017 17:17

    Published on: 13 January 2017

  16. Research article

    Are risk predicting models useful for estimating survival of patients with rheumatoid arthritis-associated interstitial lung disease?

    Risk predicting models have been applied in idiopathic pulmonary fibrosis (IPF), but still not validated in patients with rheumatoid arthritis-associated interstitial lung disease (RA-ILD). The purpose of this...

    Hanna M. Nurmi, Minna K. Purokivi, Miia S. Kärkkäinen, Hannu-Pekka Kettunen, Tuomas A. Selander and Riitta L. Kaarteenaho

    BMC Pulmonary Medicine 2017 17:16

    Published on: 13 January 2017

  17. Research article

    Identification and validation of differentially expressed transcripts by RNA-sequencing of formalin-fixed, paraffin-embedded (FFPE) lung tissue from patients with Idiopathic Pulmonary Fibrosis

    Idiopathic Pulmonary Fibrosis (IPF) is a lethal lung disease of unknown etiology. A major limitation in transcriptomic profiling of lung tissue in IPF has been a dependence on snap-frozen fresh tissues (FF). I...

    Milica Vukmirovic, Jose D. Herazo-Maya, John Blackmon, Vesna Skodric-Trifunovic, Dragana Jovanovic, Sonja Pavlovic, Jelena Stojsic, Vesna Zeljkovic, Xiting Yan, Robert Homer, Branko Stefanovic and Naftali Kaminski

    BMC Pulmonary Medicine 2017 17:15

    Published on: 12 January 2017

  18. Research article

    Effects of treadmill exercise versus Flutter® on respiratory flow and sputum properties in adults with cystic fibrosis: a randomised, controlled, cross-over trial

    Treadmill exercise and airway clearance with the Flutter® device have previously been shown to improve mucus clearance mechanisms in people with cystic fibrosis (CF) but have not been compared. It is therefore...

    Tiffany J. Dwyer, Rahizan Zainuldin, Evangelia Daviskas, Peter T. P. Bye and Jennifer A. Alison

    BMC Pulmonary Medicine 2017 17:14

    Published on: 11 January 2017

  19. Research article

    What patients really think about asthma guidelines: barriers to guideline implementation from the patients’ perspective

    Treatment of asthma does not always comply with asthma guidelines (AG). This may be rooted in direct or indirect resistance on the doctors’ and/or patients’ side or be caused by the healthcare system. To asses...

    H. Lingner, B. Burger, P. Kardos, C. P. Criée, H. Worth and E. Hummers-Pradier

    BMC Pulmonary Medicine 2017 17:13

    Published on: 11 January 2017

  20. Research article

    Recurrent pneumonia among Japanese adults: disease burden and risk factors

    In Japan and other societies with rapidly aging populations, recurrent pneumonia (RP) is a major clinical problem yet only limited information exists regarding the burden of this disease.

    Tomoko Ishifuji, Eiichiro Sando, Norihiro Kaneko, Motoi Suzuki, Paul E. Kilgore, Koya Ariyoshi, Konosuke Morimoto, Naoto Hosokawa, Makito Yaegashi and Masahiro Aoshima

    BMC Pulmonary Medicine 2017 17:12

    Published on: 11 January 2017

  21. Research article

    Effects of ventilator settings, nebulizer and exhalation port position on albuterol delivery during non-invasive ventilation: an in-vitro study

    Few studies have investigated the factors affecting aerosol delivery during non-invasive ventilation (NIV). Our aim was to investigate, using a bench-top model, the effect of different ventilator settings and ...

    Yuda Sutherasan, Lorenzo Ball, Pasquale Raimondo, Valentina Caratto, Elisa Sanguineti, Federico Costantino, Maurizio Ferretti, Robert M. Kacmarek and Paolo Pelosi

    BMC Pulmonary Medicine 2017 17:9

    Published on: 10 January 2017

  22. Research article

    Implementing flexible bronchoscopy in least developed countries according to international guidelines is feasible and sustainable: example from Phnom-Penh, Cambodia

    Flexible bronchoscopy is pivotal for the diagnosis of most respiratory diseases. A flexible bronchoscopy unit (FBU) was created in 2008 in the Preah Kossamak university hospital (Phnom Penh, Cambodia) through ...

    Martin Veaudor, Sébastien Couraud, Sophors Chan, Chanraksmey Choun, Pisethmorokoth Keo, Virginie Avrillon, Pierre-Jean Souquet and Chanty Ny

    BMC Pulmonary Medicine 2017 17:10

    Published on: 10 January 2017

  23. Study protocol

    Multi-center, randomized, placebo-controlled trial of nocturnal oxygen therapy in chronic obstructive pulmonary disease: a study protocol for the INOX trial

    Long-term oxygen therapy (LTOT) is the only component of the management of chronic obstructive pulmonary disease (COPD) that improves survival in patients with severe daytime hypoxemia. LTOT is usually provide...

    Yves Lacasse, Sarah Bernard, Frédéric Sériès, Van Hung Nguyen, Jean Bourbeau, Shawn Aaron and François Maltais

    BMC Pulmonary Medicine 2017 17:8

    Published on: 9 January 2017

  24. Research article

    End-tidal capnographic monitoring to detect apnea episodes during flexible bronchoscopy under sedation

    Apnea developing as a result of oversedation is a potential clinical problem in patients undergoing flexible bronchoscopy (FB) under sedation. However, there are no reports of evaluation using a standardized m...

    Tsukasa Ishiwata, Kenji Tsushima, Mai Fujie, Kenichi Suzuki, Kosuke Hirota, Mitsuhiro Abe, Naoko Kawata, Jiro Terada and Koichiro Tatsumi

    BMC Pulmonary Medicine 2017 17:7

    Published on: 7 January 2017

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