| | |
Baseline
|
T = 2.5 hrs
|
T = 24 hrs
|
T = 72 hrs
|
|---|
|
RVED (mm)
|
Placebo
|
41 ± 8
|
43 ± 8
|
42 ± 7
|
38 ± 5
|
| |
Epoprostenol
|
41 ± 8
|
43 ± 7
|
38 ± 6
|
40 ± 9
|
|
Systolic PAP (mmHg)
|
Placebo
|
47 ± 11
|
48 ± 17
|
41 ± 7
|
46 ± 9
|
| |
Epoprostenol
|
57 ± 14
|
50 ± 19
|
55 ± 22
|
50 ± 14
|
|
TAPSE (cm)
|
Placebo
|
2.0 ± 0.5
|
2.1 ± 0.6
|
2.3 ± 0.3
|
2.2 ± 0.6
|
| |
Epoprostenol
|
1.9 ± 0.6
|
1.9 ± 0.5
|
2.0 ± 0.6
|
2.0 ± 0.5
|
|
RVFAC (%)
|
Placebo
|
24 ± 18
|
28 ± 21
|
25 ± 17
|
29 ± 16
|
| |
Epoprostenol
|
34 ± 24
|
34 ± 10
|
35 ± 16
|
33 ± 10
|
|
RAD (cm)
|
Placebo
|
4.7 ± 0.7
|
4.4 ± 0.8
|
4.7 ± 1.3
|
4.3 ± 0.9
|
| |
Epoprostenol
|
4.2 ± 0.9
|
4.6 ± 1.0
|
4.1 ± 1.2
|
4.1 ± 1.0
|
|
RV/LV
|
Placebo
|
0.82 ± 0.16
|
0.88 ± 0.10
|
0.89 ± 0.15
|
0.69 ± 0.07
|
| |
Epoprostenol
|
0.87 ± 0.24
|
0.97 ± 0.14
|
0.77 ± 0.23
|
0.79 ± 0.15
|
|
ABPs (mmHg)
|
Placebo
|
117 ± 6
|
114 ± 12
|
118 ± 19
|
124 ± 11
|
| |
Epoprostenol
|
125 ± 27
|
123 ± 26
|
118 ± 18
|
134 ± 29
|
|
ABPd (mmHg)
|
Placebo
|
70 ± 10
|
71 ± 6
|
72 ± 12
|
74 ± 11
|
| |
Epoprostenol
|
66 ± 14
|
70 ± 12
|
71 ± 11
|
72 ± 11
|
|
ABPm (mmHg)
|
Placebo
|
86 ± 10
|
86 ± 7
|
87 ± 11
|
91 ± 10
|
| |
Epoprostenol
|
82 ± 15
|
88 ± 6
|
87 ± 12
|
93 ± 12
|
|
CO (l/min)
|
Placebo
|
6.2 ± 1.7
|
6.5 ± 0.6
|
6.7 ± 1.2
|
5.4 ± 1.2
|
| |
Epoprostenol
|
5.5 ± 1.2
|
6.4 ± 1.1
|
5.9 ± 0.8
|
6.0 ± 0.8
|
|
NT-proBNP (pg/ml)
|
Placebo
|
1467 (39-8549)
|
925 (33-8322)
|
694 (84-6954)
|
343 (130-7240)
|
| |
Epoprostenol
|
3885 (270-12339)
|
3043 (352-4811)
|
3089 (415-4892)
|
614 (147-4268)
|
|
Troponin T (ng/ml)
|
Placebo
|
0.01 (0.01-0.09)
|
0.01 (0.01-0.09)
|
0.01 (0.01-0.07)
|
0.01 (0.01-0.04)
|
| |
Epoprostenol
|
0.03 (0.01-0.13)
|
0.02 (0.01-0.12)
|
0.01 (0.01-0.07)
|
0.01 (0.01-0.08)
|
-
Definition of abbreviations: PAP = pulmonary artery pressure; TAPSE = tricuspid annular plane systolic excursion; RVFAC = right ventricular fractional area change; RAD = right atrial end-diastolic diameter; RV/LV = right/left ventricular end-diastolic diameter; ABPs = systolic arterial blood pressure; ABPd = diastolic arterial blood pressure; ABPm = mean arterial blood pressure; RVED = right ventricular end-diastolic diameter;
- Values are given as the mean ± SD. NT-proBNP and troponin T are given as median (range).
- At no time point significant differences of these parameters between treatment groups were observed (P > 0.20). Data for NT-proBNP and Troponin T were log-transformed for statistical testing.
