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Table 2 Changes in echocardiographic parameters, blood pressure and biochemical variables associated with acute right ventricular overload

From: No effect of epoprostenol on right ventricular diameter in patients with acute pulmonary embolism: a randomized controlled trial

   Baseline T = 2.5 hrs T = 24 hrs T = 72 hrs
RVED (mm) Placebo 41 ± 8 43 ± 8 42 ± 7 38 ± 5
  Epoprostenol 41 ± 8 43 ± 7 38 ± 6 40 ± 9
Systolic PAP (mmHg) Placebo 47 ± 11 48 ± 17 41 ± 7 46 ± 9
  Epoprostenol 57 ± 14 50 ± 19 55 ± 22 50 ± 14
TAPSE (cm) Placebo 2.0 ± 0.5 2.1 ± 0.6 2.3 ± 0.3 2.2 ± 0.6
  Epoprostenol 1.9 ± 0.6 1.9 ± 0.5 2.0 ± 0.6 2.0 ± 0.5
RVFAC (%) Placebo 24 ± 18 28 ± 21 25 ± 17 29 ± 16
  Epoprostenol 34 ± 24 34 ± 10 35 ± 16 33 ± 10
RAD (cm) Placebo 4.7 ± 0.7 4.4 ± 0.8 4.7 ± 1.3 4.3 ± 0.9
  Epoprostenol 4.2 ± 0.9 4.6 ± 1.0 4.1 ± 1.2 4.1 ± 1.0
RV/LV Placebo 0.82 ± 0.16 0.88 ± 0.10 0.89 ± 0.15 0.69 ± 0.07
  Epoprostenol 0.87 ± 0.24 0.97 ± 0.14 0.77 ± 0.23 0.79 ± 0.15
ABPs (mmHg) Placebo 117 ± 6 114 ± 12 118 ± 19 124 ± 11
  Epoprostenol 125 ± 27 123 ± 26 118 ± 18 134 ± 29
ABPd (mmHg) Placebo 70 ± 10 71 ± 6 72 ± 12 74 ± 11
  Epoprostenol 66 ± 14 70 ± 12 71 ± 11 72 ± 11
ABPm (mmHg) Placebo 86 ± 10 86 ± 7 87 ± 11 91 ± 10
  Epoprostenol 82 ± 15 88 ± 6 87 ± 12 93 ± 12
CO (l/min) Placebo 6.2 ± 1.7 6.5 ± 0.6 6.7 ± 1.2 5.4 ± 1.2
  Epoprostenol 5.5 ± 1.2 6.4 ± 1.1 5.9 ± 0.8 6.0 ± 0.8
NT-proBNP (pg/ml) Placebo 1467 (39-8549) 925 (33-8322) 694 (84-6954) 343 (130-7240)
  Epoprostenol 3885 (270-12339) 3043 (352-4811) 3089 (415-4892) 614 (147-4268)
Troponin T (ng/ml) Placebo 0.01 (0.01-0.09) 0.01 (0.01-0.09) 0.01 (0.01-0.07) 0.01 (0.01-0.04)
  Epoprostenol 0.03 (0.01-0.13) 0.02 (0.01-0.12) 0.01 (0.01-0.07) 0.01 (0.01-0.08)
  1. Definition of abbreviations: PAP = pulmonary artery pressure; TAPSE = tricuspid annular plane systolic excursion; RVFAC = right ventricular fractional area change; RAD = right atrial end-diastolic diameter; RV/LV = right/left ventricular end-diastolic diameter; ABPs = systolic arterial blood pressure; ABPd = diastolic arterial blood pressure; ABPm = mean arterial blood pressure; RVED = right ventricular end-diastolic diameter;
  2. Values are given as the mean ± SD. NT-proBNP and troponin T are given as median (range).
  3. At no time point significant differences of these parameters between treatment groups were observed (P > 0.20). Data for NT-proBNP and Troponin T were log-transformed for statistical testing.