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Table 2 Changes in echocardiographic parameters, blood pressure and biochemical variables associated with acute right ventricular overload

From: No effect of epoprostenol on right ventricular diameter in patients with acute pulmonary embolism: a randomized controlled trial

  

Baseline

T = 2.5 hrs

T = 24 hrs

T = 72 hrs

RVED (mm)

Placebo

41 ± 8

43 ± 8

42 ± 7

38 ± 5

 

Epoprostenol

41 ± 8

43 ± 7

38 ± 6

40 ± 9

Systolic PAP (mmHg)

Placebo

47 ± 11

48 ± 17

41 ± 7

46 ± 9

 

Epoprostenol

57 ± 14

50 ± 19

55 ± 22

50 ± 14

TAPSE (cm)

Placebo

2.0 ± 0.5

2.1 ± 0.6

2.3 ± 0.3

2.2 ± 0.6

 

Epoprostenol

1.9 ± 0.6

1.9 ± 0.5

2.0 ± 0.6

2.0 ± 0.5

RVFAC (%)

Placebo

24 ± 18

28 ± 21

25 ± 17

29 ± 16

 

Epoprostenol

34 ± 24

34 ± 10

35 ± 16

33 ± 10

RAD (cm)

Placebo

4.7 ± 0.7

4.4 ± 0.8

4.7 ± 1.3

4.3 ± 0.9

 

Epoprostenol

4.2 ± 0.9

4.6 ± 1.0

4.1 ± 1.2

4.1 ± 1.0

RV/LV

Placebo

0.82 ± 0.16

0.88 ± 0.10

0.89 ± 0.15

0.69 ± 0.07

 

Epoprostenol

0.87 ± 0.24

0.97 ± 0.14

0.77 ± 0.23

0.79 ± 0.15

ABPs (mmHg)

Placebo

117 ± 6

114 ± 12

118 ± 19

124 ± 11

 

Epoprostenol

125 ± 27

123 ± 26

118 ± 18

134 ± 29

ABPd (mmHg)

Placebo

70 ± 10

71 ± 6

72 ± 12

74 ± 11

 

Epoprostenol

66 ± 14

70 ± 12

71 ± 11

72 ± 11

ABPm (mmHg)

Placebo

86 ± 10

86 ± 7

87 ± 11

91 ± 10

 

Epoprostenol

82 ± 15

88 ± 6

87 ± 12

93 ± 12

CO (l/min)

Placebo

6.2 ± 1.7

6.5 ± 0.6

6.7 ± 1.2

5.4 ± 1.2

 

Epoprostenol

5.5 ± 1.2

6.4 ± 1.1

5.9 ± 0.8

6.0 ± 0.8

NT-proBNP (pg/ml)

Placebo

1467 (39-8549)

925 (33-8322)

694 (84-6954)

343 (130-7240)

 

Epoprostenol

3885 (270-12339)

3043 (352-4811)

3089 (415-4892)

614 (147-4268)

Troponin T (ng/ml)

Placebo

0.01 (0.01-0.09)

0.01 (0.01-0.09)

0.01 (0.01-0.07)

0.01 (0.01-0.04)

 

Epoprostenol

0.03 (0.01-0.13)

0.02 (0.01-0.12)

0.01 (0.01-0.07)

0.01 (0.01-0.08)

  1. Definition of abbreviations: PAP = pulmonary artery pressure; TAPSE = tricuspid annular plane systolic excursion; RVFAC = right ventricular fractional area change; RAD = right atrial end-diastolic diameter; RV/LV = right/left ventricular end-diastolic diameter; ABPs = systolic arterial blood pressure; ABPd = diastolic arterial blood pressure; ABPm = mean arterial blood pressure; RVED = right ventricular end-diastolic diameter;
  2. Values are given as the mean ± SD. NT-proBNP and troponin T are given as median (range).
  3. At no time point significant differences of these parameters between treatment groups were observed (P > 0.20). Data for NT-proBNP and Troponin T were log-transformed for statistical testing.
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BMC Pulmonary Medicine

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