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Table 1 Characteristics of the patients

From: Bilirubin as a prognostic marker in patients with pulmonary arterial hypertension

Variables All patients Hyper-
bilirubinemia
Normo-
bilirubinemia
p Value
  n = 37 n = 6 n = 31  
Age, yrs 49 ± 18 53 ± 15 48 ± 19 0.62
Women 29 (78) 1 7 0.75
Height, cm 153 ± 20 152 ± 7 153 ± 19 0.36
Body weight, kg 50 ± 10 43 ± 10 51 ± 9 0.04
Systolic blood pressure, mm Hg 113 ± 20 104 ± 12 114 ± 22 0.26
Diastolic blood pressure, mm Hg 70 ± 14 61 ± 11 71 ± 14 0.10
Heart rate, beats per minute 88 ± 14 95 ± 8 86 ± 15 0.18
WHO Functional class II/III/IV 15/12/10 (41/32/27) 1/0/5 14/12/5 0.003
Idiopathic/CTD-associated 18/19 (49/51) 4/2 14/17 0.34
Treatment at baseline     
   Epoprostenol alone 11 (30) 4 7  
   Sildenafil alone 4 (11) 0 4  
   Bosentan alone 6 (16) 0 6  
   Beraprost alone 13 (35) 2 11  
   Epoprostenol + Sildenafil 1 (3) 0 1  
   Sildenafil + Beraprost 1 (3) 0 1  
   Sildenafil + Bosentan + Beraprost 1 (3) 0 1  
Treatment at the end of follow-up     
   Epoprostenol alone 17 (46) 5 12  
   Sildenafil alone 5 (14) 0 5  
   Bosentan alone 5 (14) 0 5  
   Beraprost alone 6 (16) 0 6  
   Epoprostenol + Sildenafil 3 (8) 1 2  
   Sildenafil + Beraprost 1 (3) 0 1  
Mean right atrial pressure, mm Hg* 8 ± 4 14 ± 2 7 ± 3 <0.001
Mean pulmonary arterial pressure, mm Hg* 52 ± 20 71 ± 4 50 ± 19 0.002
Cardiac index, l/min/m2 2.87 ± 0.80 2.61 ± 0.90 2.90 ± 0.81 0.46
Doppler RV index 0.64 ± 0.30 0.86 ± 0.23 0.58 ± 0.29 0.04
Plasma BNP, pg/ml 170 [70, 796] 1062 [833, 1210] 337 [141, 959] 0.003
AST, U/L 34 ± 38 58 ± 87 29 ± 18 0.46
ALT, U/L 36 ± 55 67 ± 129 29 ± 23 0.51
LDH, U/L 247 ± 82 315 ± 167 234 ± 48 0.29
Bilirubin, mg/dL 0.9 ± 0.9 2.4 ± 1.5 0.6 ± 0.3 N/A
Uric acid, mg/dL 6.8 ± 2.5 7.6 ± 4.7 6.6 ± 1.8 0.64
  1. Values are shown as a number (%) or as a mean ± SD as appropriate; ALT = alanine aminotransferase, AST = aspartate aminotransferase, BNP = brain natriuretic peptide; CTD = connective tissue disorder; LDH = lactate dehydrogenase, PAH = pulmonary arterial hypertension, RV = right ventricle, WHO = World Health Organization. *n = 26, Data are given as a median [25th, 75th percentile].