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Table 1 Characteristics of the patients

From: Bilirubin as a prognostic marker in patients with pulmonary arterial hypertension

Variables

All patients

Hyper-

bilirubinemia

Normo-

bilirubinemia

p Value

 

n = 37

n = 6

n = 31

 

Age, yrs

49 ± 18

53 ± 15

48 ± 19

0.62

Women

29 (78)

1

7

0.75

Height, cm

153 ± 20

152 ± 7

153 ± 19

0.36

Body weight, kg

50 ± 10

43 ± 10

51 ± 9

0.04

Systolic blood pressure, mm Hg

113 ± 20

104 ± 12

114 ± 22

0.26

Diastolic blood pressure, mm Hg

70 ± 14

61 ± 11

71 ± 14

0.10

Heart rate, beats per minute

88 ± 14

95 ± 8

86 ± 15

0.18

WHO Functional class II/III/IV

15/12/10 (41/32/27)

1/0/5

14/12/5

0.003

Idiopathic/CTD-associated

18/19 (49/51)

4/2

14/17

0.34

Treatment at baseline

    

   Epoprostenol alone

11 (30)

4

7

 

   Sildenafil alone

4 (11)

0

4

 

   Bosentan alone

6 (16)

0

6

 

   Beraprost alone

13 (35)

2

11

 

   Epoprostenol + Sildenafil

1 (3)

0

1

 

   Sildenafil + Beraprost

1 (3)

0

1

 

   Sildenafil + Bosentan + Beraprost

1 (3)

0

1

 

Treatment at the end of follow-up

    

   Epoprostenol alone

17 (46)

5

12

 

   Sildenafil alone

5 (14)

0

5

 

   Bosentan alone

5 (14)

0

5

 

   Beraprost alone

6 (16)

0

6

 

   Epoprostenol + Sildenafil

3 (8)

1

2

 

   Sildenafil + Beraprost

1 (3)

0

1

 

Mean right atrial pressure, mm Hg*

8 ± 4

14 ± 2

7 ± 3

<0.001

Mean pulmonary arterial pressure, mm Hg*

52 ± 20

71 ± 4

50 ± 19

0.002

Cardiac index, l/min/m2

2.87 ± 0.80

2.61 ± 0.90

2.90 ± 0.81

0.46

Doppler RV index

0.64 ± 0.30

0.86 ± 0.23

0.58 ± 0.29

0.04

Plasma BNP, pg/ml

170 [70, 796]

1062 [833, 1210]

337 [141, 959]

0.003

AST, U/L

34 ± 38

58 ± 87

29 ± 18

0.46

ALT, U/L

36 ± 55

67 ± 129

29 ± 23

0.51

LDH, U/L

247 ± 82

315 ± 167

234 ± 48

0.29

Bilirubin, mg/dL

0.9 ± 0.9

2.4 ± 1.5

0.6 ± 0.3

N/A

Uric acid, mg/dL

6.8 ± 2.5

7.6 ± 4.7

6.6 ± 1.8

0.64

  1. Values are shown as a number (%) or as a mean ± SD as appropriate; ALT = alanine aminotransferase, AST = aspartate aminotransferase, BNP = brain natriuretic peptide; CTD = connective tissue disorder; LDH = lactate dehydrogenase, PAH = pulmonary arterial hypertension, RV = right ventricle, WHO = World Health Organization. *n = 26, Data are given as a median [25th, 75th percentile].