Skip to main content

Table 2 Results of Cox proportional hazard analyses

From: Bilirubin as a prognostic marker in patients with pulmonary arterial hypertension

  Univariate Model 1 Model 2
Variables p Hazard ratio
(95% CI)
p Hazard ratio
(95% CI)
p Hazard ratio
(95% CI)
Age, year 0.51 1.01
(0.98--1.04)
    
Women 0.71 0.78
(0.22--2.83)
    
CTD-associated 0.29 0.49
(0.16--1.46)
    
Mean RA pressure, mm Hg* 0.05 1.19
(1.00--1.43)
    
Mean PA pressure, mm Hg* 0.34 0.99
(0.95--1.02)
    
Cardiac index, L/min/m2 0.70 1.14
(0.58--2.24)
    
WHO functional class <0.001 4.95
(2.17--11.32)
0.009 3.30
(1.35--8.03)
  
Doppler RV index 0.17 3.03
(0.61--14.99)
    
BNP, lognormal pg/dL 0.001 2.79
(1.55--5.04)
   0.004 2.35
(1.31 -- 4.21)
Elevated AST 0.34 0.37
(0.05--2.84)
    
Elevated ALT 0.30 0.34
(0.04--2.60)
    
Elevated LDH 0.17 2.10
(0.73--6.12)
    
Hyperbilirubinemia <0.001 13.31
(3.91--45.30)
0.02 4.81
(1.24--18.73)
  
Bilirubin, mg/dL 0.001 3.64
(1.73--7.68)
   0.02 2.28
(1.15 -- 4.52)
  1. BNP = brain natriuretic peptide; CTD = connective tissue disorder; PA = pulmonary artery, RV = right ventricle, WHO = World Health Organization. *n = 26, Bivariate model using WHO functional class and hyperbilirubinemia, Bivariate model using BNP and bilirubin concentration.