CAT-354 | |||
---|---|---|---|
1 mg/kg (n = 8) | 5 mg/kg (n = 8) | 10 mg/kg (n = 3) | |
Cmax (μg/mL) | 30.3 (5.2) | 157 (34.5) | 306 (31.4) |
AUC(0-t) (μg.day/mL) | 300 (42.0) | 1691 (303) | 3106 (719) |
AUC(0-inf) (μg.day/mL) | 428 (83.3) | 2314 (393) | 3861 (662) |
t1/2 (days) | 16.6 (2.7) | 16.1 (3.6) | 11.8 (1.9) |
CL* (mL/day/kg) | 2.41 (0.5) | 2.23 (0.5) | 2.64 (0.4) |
Vd (mL/kg) | 56.7 (8.0) | 51.0 (10.4) | 44.0 (0.8) |