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Table 3 Effects of β2-agonist isomers on Mycoplasma pneumoniae (Mp) load in cultured human airway epithelial cells*

From: β2-agonists promote host defense against bacterial infection in primary human bronchial epithelial cells

 

Normal subjects

Asthma

COPD

 

Mp

Mp + CSE†

Mp

Mp + CSE

Mp

Mp + CSE

(R)-albuterol

0.03

0.16

0.03

0.24

0.43

0.14

Racemic albuterol

0.14

0.09

0.08

0.10

0.08

0.16

(S)-albuterol

0.01

0.48

0.15

0.21

0.44

0.20

(R,R)-formoterol

0.17

0.03

0.04

0.10

0.07

0.15

Racemic formoterol

0.48

0.10

0.01

0.37

0.13

0.08

(S,S)-formoterol

0.01

0.25

0.77

0.55

0.64

0.24

  1. *, Data are presented as p values. A p value ≤ 0.05 is considered statistically significant. The p values were obtained by comparing β2-agonists with no drug treatments. †, CSE = cigarette smoke extract.