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Table 3 Associations between MBC test outcome and constitutional, behavioural characteristics and markers of airway responsiveness and inflammation (percentage in column (n)) (N = 341).

From: Associations of airway inflammation and responsiveness markers in non asthmatic subjects at start of apprenticeship

  MBC- FEV1's fall <20% (N = 322) MBC FEV1's fall ≥20% (N = 19) p
Constitutional characteristics    
   Gender: Male 56.2% (181) 52.6% (10) 0.76
   Atopy in family* 37.6% (121) 52.6% (10) 0.19
   Clinical atopy† 19.9% (64) 10.5% (2) 0.55**
   Personal atopy‡ (61 missing data) 27.4% (72) 64.7% (11) <0.01**
Behavioural characteristics    
   Training track    
Bakery 36.3% (117) 26.3% (5)  
Pastry making 25.5% (82) 26.3% (5) 0.69**
Hairdressing 38.2% (123) 47.4% (9)  
   Tobacco usage status    
Non smoker 49.4% (159) 42.1% (8)  
Current smoker 47.2% (152) 52.6% (10) 0.54**
Past smoker 3.4% (11) 5.3% (1)  
Baseline FEV1§    
>80.8% 86.3% (278) 79.0% (15)  
>76.0% and <80.7% 8.7% (28) 10.5% (2) 0.31**
<76.0% 5.0% (16) 10.5% (2)  
Rrs4-16 increase post MBC test (%)
(mean (sd))
   
   <42.4% 87.3% (281) 84.2% (16)  
   >42.4% and <54.6% 6.8% (22) 10.5% (2) 0.75**
   >54.6% 5.9% (19) 5.3% (1)  
Clinical indicators of airway inflammation    
   Rhinoconjunctivitis-like symptoms|| 9.6% (31) 5.3% (1) 1.0**
   Asthma-like symptoms¶ 4.0% (13) 5.3% (1) 0.56**
Quantitative indicators of airway inflammation    
   FENO in ppb (median (first-third quartiles) 12.4 (8.9-17.6) 16.4 (10.3-35.0) 0.19††
   FENO in percent predicted according to Travers#    
<140% 87.3% (281) 73.7% (14)  
>140% and <225% 7.1% (23) 10.5% (2) 0.09**
>225% 5.6% (18) 15.8% (3)  
   Eosinophil count in nasal fluid lavage    
<1% 86.7% (279) 79.0% (15)  
>1% and <14% 6.5% (21) 10.5% (2) 0.37**
>14% 6.8% (22) 10.5% (2)  
  1. Rrs4-16: mean oscillatory resistance from 4 to 16 Hz; MBC: Methacholine Bronchial Challenge test.
  2. * asthma or allergy in siblings and/or parents; † hay fever and/or eczema in childhood and/or asthma in childhood; ‡ defined as a positive response to at least one common allergen at the Skin Prick Tests
  3. § in percent predicted according to the European Respiratory Society
  4. || in case of itchy, runny, stuffy nose, or sneezes and/or about red, burning or weeping eyes, excepted during a respiratory infection; ¶ in case of wheezing, chest tightness, shortness of breath, or cough, excepted during a respiratory infection or under exercise condition.
  5. # according to gender, tobacco usage status and personal atopy ([13])
  6. ** Fisher's exact test; †† Mann-Whitney test