Imipenem resistance of Pseudomonas in pneumonia: a systematic literature review

BMC Pulmonary Medicine

Table 2 Results: P. aeruginosa clinical and microbiologic success, baseline and emergent resistance rates*

First author, year	Study arm	PA isolates (n)	Clinical success (%)	Microbiologic eradication (%)	Resistance at baseline (%)	Emergent resistance (%)
Chastre, 2008 [39]	Imipenem	25	42.9	35.7	24.0	52.6
	Comparator	28	80.0	65.0	0.0	35.7
Yanagihara, 2005 [40]	Imipenem	4		50.0
	Comparator	3		0.0
Joshi, 2006 [42]	Imipenem	17		70.6
	Comparator	18		76.5
Romanelli, 2006 [43]	Imipenem	1	0.0	0.0
	Comparator	1	0.0	0.0
Shorr, 2005 [44]	Imipenem	18^†	72.0			5.6
	Comparator	16	85.0			6.3
Zanetti, 2003 [45]	Imipenem	32			15.6	28.1
	Comparator	27			7.4	11.1
West, 2003 [46]	Imipenem	17^†	41.2	29.4
	Comparator	17	64.7	58.8
Torres, 2000 [47]	Imipenem	12	66.0	25.0		33.0
	Comparator	14	71.0	50.0		7.0
Bartoloni, 1999 [48]	Imipenem	3	66.6	66.7
	Comparator	1	100.0	100.0
Jaccard, 1998 [49]	Imipenem	24	50.0		4.2	25.0
	Comparator	21	90.5		0.0	4.8
Ho, 1997 [51]	Imipenem	2	50.0
	Comparator	3	100.0
Raad, 1996 [52]	Imipenem	1	0.0
	Comparator	4	75.0
Vic, 1996 [53]	Imipenem	1		100.0
	Comparator	19		100.0
Bohme, 1995 [54]	Imipenem	3	66.0	66.0
	Comparator	0	NA	NA
Siami, 1995 [55]	Imipenem	9				77.8
	Comparator	12				41.7
Cometta, 1994 [56]	Imipenem	24		55.6		33.3
	Comparator	23		50.0		56.5
Fink, 1994 [57]	Imipenem	44		25.0		50.0
	Comparator	47		27.7		28.0
Norrby, 1993 [58]	Imipenem	14	42.1			42.9
	Comparator	16	82.4			6.3
Pooled rates	Imipenem	251	45.2	47.6	14.6	38.7
	Comparator	270	74.9	52.8	2.5	21.9

*Limited to studies reporting at least one of these outcomes; empty cells indicate that the corresponding data were not reported
^†Although the total pseudomonal isolates in the two arms of each analysis add up to the same number (n = 34), the distribution between the arms is different presumably due to reclassification of a single PA isolate from the levofloxacin to the imipenem arm, which occurred between the West [46] publication and the Shorr [44] analysis.
PA:Pseudomonas aeruginosa; NA: not applicable

ISSN: 1471-2466