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Table 2 Diagnostic accuracy variables of the studies included in the meta-analysis.

From: Diagnostic accuracy of pleural fluid NT-pro-BNP for pleural effusions of cardiac origin: a systematic review and meta-analysis

Study No.
Pts/Pes
TP FN TN FP Se Sp NT-pro-BNP Threshold* Average
NT-pro-BNP
Misclassification Correlation Statistic
           Light's NT-pro-BNP§  
Tomcsanyi et al[16] 28 14 0 14 0 100% 100% ≥ 599 8236 1/14
(7%)
0/1 R 2 = 0.95
p < 0.0001
Porcel et al[17] 117 40 4 68 5 91% 93% ≥ 1500 6931 10/35
(29%)
2/10 NR
Kolditz et al[18] 93 23 2 63 5 92% 93% ≥ 4000 10427 9/25
(36%)
0/9 S = 0.96
p < 0.001
Porcel et al[19] 93 49 4 35 5 92% 87% ≥ 1500 6106 8/53
(15%)
2/8 S = 0.96
p < 0.001
Liao et al[20] 40 10 0 29 1 100% 97% ≥ 2220 5390 NR NR NR
Han et al[21] 240 81 1 156 2 99% 99% ≥ 1714 3310 28/82
(34%)
1/28 R 2 = 0.93
p < 0.001
Seyhan et al[22] 115 47 4 61 3 92% 95% ≥ 1092 N/A 17/51
(33%)
N/A N/A
Porcel et al[23] 181 84 6 81 10 93% 89% ≥ 1500 6203 20/90
(22%)
4/20 NR
Bayram et al[24] 133 48 3 78 4 94% 95% ≥ 925 4468 19/51
(37%)
0/19 R 2 = 0.91
p < 0.001
Long et al[25] 80 16 4 44 16 80% 73% ≥ 2000 4189 NR NR NR
  1. * = pleural fluid NT-pro-BNP threshold in pg/mL; † = average pleural fluid NT-pro-BNP in CHF effusions in pg/mL; = misclassification of CHF effusions as exudates by Light's criteria; § = misclassification of the CHF effusions already misclassified by Light's criteria now misclassified by NT-pro-BNP; = correlation between serum and pleural fluid NT-pro-BNP levels; ¶ = threshold from 599 to 1457 pg/mL resulted in 100% sensitivity and specificity; N/A = not available because only abstract available for data extraction; No. = number; NR = not recorded; Pes = pleural effusions; Pts = patients; R 2 = Pearson coefficient of correlation; S = Spearman's coefficient of rank correlation; Se = sensitivity; Sp = specificity.