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Table 5 Cost-effectiveness of screening strategies when probabilities are varied in the sensitivity analysis.

From: Different screening strategies (single or dual) for the diagnosis of suspected latent tuberculosis: a cost effectiveness analysis

Probability Variable Incremental cost per Active TB case prevented (British Pounds; £'s)
  TST T-SPOT. TB QFT-GIT TST/T-SPOT. TB TST/QFT-GIT
Base-case estimates £47,8405# £39,7123 £42,0514 £37,2061 £37,6992
Prevalence      
0.1 £109,1205 £69,4623 £80,1604 £55,1181 £58,3212
0.4 £40,1805 £35,9943 £37,2874 £34,9671 £35,1222
T-SPOT. TB sensitivity      
0.83 £47,8405 £41,8633 £42,0514 £38,9942 £37,6991
0.97 £47,8405 £39,4063 £42,0514 £36,9511 £37,6992
T-SPOT. TB specificity      
0.92 £47,8405 £46,0904 £42,0513 £38,7072 £37,6991
0.99 £47,8405 £40,5103 £42,0514 £37,3941 £37,6992
QFT-GIT sensitivity      
0.85 £47,8405 £39,7123 £42,8624 £37,2061 £38,3052
0.95 £47,8405 £39,7123 £40,9624 £37,2062 £36,8871
QFT-GIT specificity      
0.9 £47,8405 £39,7123 £46,3024 £37,2061 £38,7012
0.97 £47,8405 £39,7123 £40,3504 £37,2061 £37,2992
TST sensitivity      
0.69 £53,1745 £39,7122 £42,0514 £39,0391 £39,7783
0.95 £45,4195 £39,7123 £42,0514 £36,3741 £36,7562
TST specificity      
0.65 £61,2055 £39,7122 £42,0514 £39,0441 £40,0553
0.9 £38,9313 £39,7124 £42,0515 £35,9811 £36,1292
Starting LTBI treatment      
0.55 £50,1965 £46,4743 £47,9514 £42,8281 £43,0912
0.95 £47,0225 £37,3643 £40,0014 £35,2531 £35,8272
Severe INH hepatitis      
0.001 £47,6535 £39,5763 £41,9234 £37,0731 £37,5632
0.023 £49,7435 £41,1003 £43,3414 £38,5591 £39,0822
Efficacy of 6 months INH treatment      
0.5 £64,4575 £53,8943 £56,9184 £50,6371 £51,2782
0.93 £31,1545 £25,4723 £27,1144 £23,7191 £24,0642
TST return rate      
0.95 £47,6805 £39,7123 £42,0514 £37,0371 £37,5192
0.65 £49,0125 £39,7123 £42,0514 £38,4391 £39,0162
Post exposure TB      
0.01 £52,4125 £44,2843 £46,6194 £41,7781 £42,2712
0.05 £40,2215 £32,0933 £34,4374 £29,5861 £30,0802
  1. # The superscripts 1-5 indicate the cost-effectiveness ranking; (1) indicates most cost effective strategy while (5) indicates the least cost-effective strategy. (LTBI - latent tuberculosis infection, TST - tuberculin skin test, INH - isoniazid, QFT-GIT - Quantiferon-TB Gold-In-Tube)