Different screening strategies (single or dual) for the diagnosis of suspected latent tuberculosis: a cost effectiveness analysis

Pooran, Anil; Booth, Helen; Miller, Robert F; Scott, Geoff; Badri, Motasim; Huggett, Jim F; Rook, Graham; Zumla, Alimuddin; Dheda, Keertan

doi:10.1186/1471-2466-10-7

Table 5 Cost-effectiveness of screening strategies when probabilities are varied in the sensitivity analysis.

From: Different screening strategies (single or dual) for the diagnosis of suspected latent tuberculosis: a cost effectiveness analysis

Probability Variable	Incremental cost per Active TB case prevented (British Pounds; £'s)
	TST	T-SPOT. TB	QFT-GIT	TST/T-SPOT. TB	TST/QFT-GIT
Base-case estimates	£47,840^5#	£39,712³	£42,051⁴	£37,206¹	£37,699²
Prevalence
0.1	£109,120⁵	£69,462³	£80,160⁴	£55,118¹	£58,321²
0.4	£40,180⁵	£35,994³	£37,287⁴	£34,967¹	£35,122²
T-SPOT. TB sensitivity
0.83	£47,840⁵	£41,863³	£42,051⁴	£38,994²	£37,699¹
0.97	£47,840⁵	£39,406³	£42,051⁴	£36,951¹	£37,699²
T-SPOT. TB specificity
0.92	£47,840⁵	£46,090⁴	£42,051³	£38,707²	£37,699¹
0.99	£47,840⁵	£40,510³	£42,051⁴	£37,394¹	£37,699²
QFT-GIT sensitivity
0.85	£47,840⁵	£39,712³	£42,862⁴	£37,206¹	£38,305²
0.95	£47,840⁵	£39,712³	£40,962⁴	£37,206²	£36,887¹
QFT-GIT specificity
0.9	£47,840⁵	£39,712³	£46,302⁴	£37,206¹	£38,701²
0.97	£47,840⁵	£39,712³	£40,350⁴	£37,206¹	£37,299²
TST sensitivity
0.69	£53,174⁵	£39,712²	£42,051⁴	£39,039¹	£39,778³
0.95	£45,419⁵	£39,712³	£42,051⁴	£36,374¹	£36,756²
TST specificity
0.65	£61,205⁵	£39,712²	£42,051⁴	£39,044¹	£40,055³
0.9	£38,931³	£39,712⁴	£42,051⁵	£35,981¹	£36,129²
Starting LTBI treatment
0.55	£50,196⁵	£46,474³	£47,951⁴	£42,828¹	£43,091²
0.95	£47,022⁵	£37,364³	£40,001⁴	£35,253¹	£35,827²
Severe INH hepatitis
0.001	£47,653⁵	£39,576³	£41,923⁴	£37,073¹	£37,563²
0.023	£49,743⁵	£41,100³	£43,341⁴	£38,559¹	£39,082²
Efficacy of 6 months INH treatment
0.5	£64,457⁵	£53,894³	£56,918⁴	£50,637¹	£51,278²
0.93	£31,154⁵	£25,472³	£27,114⁴	£23,719¹	£24,064²
TST return rate
0.95	£47,680⁵	£39,712³	£42,051⁴	£37,037¹	£37,519²
0.65	£49,012⁵	£39,712³	£42,051⁴	£38,439¹	£39,016²
Post exposure TB
0.01	£52,412⁵	£44,284³	£46,619⁴	£41,778¹	£42,271²
0.05	£40,221⁵	£32,093³	£34,437⁴	£29,586¹	£30,080²

^# The superscripts ^1-5 indicate the cost-effectiveness ranking; ⁽¹⁾ indicates most cost effective strategy while ⁽⁵⁾ indicates the least cost-effective strategy. (LTBI - latent tuberculosis infection, TST - tuberculin skin test, INH - isoniazid, QFT-GIT - Quantiferon-TB Gold-In-Tube)

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ISSN: 1471-2466

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