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Table 1 Baseline characteristics of the study participants providing BAL fluid and biopsy specimens

From: S100A7/psoriasin expression in the human lung: unchanged in patients with COPD, but upregulated upon positive S. aureusdetection

Characteristic

Healthy controls

COPD patients

  

Stage 1

Stage 2

Stage 3

Stage 4

Number

10

2

13

15

4

Age [years]

31.3 ± 7.8 (20-46)

73.5 ± 7.8 (68-79)

66.9 ± 9.9 (52-82)

66.4 ± 7.5 (46-77)

58.3 ± 3.6 (55-63)

Sex [M/F]

3/7

1/1

9/4

10/5

2/2

BMI

22.7 ± 1.9 (20.0-26.7)

27.2 ± 0.2 (27.0-27.3)

28.3-5.8 (22.5-44.6)

25.4 ± 4.7 (16.0-35.5)

21.3 ± 3.7 (16.2-24.5)

Pack years

2.9 ± 2.8 (1-7)

50.0 ± 14.1 (40-60)

41.9 ± 19.3 (10-85)

39.7 ± 16.6 (5-65)

42.5 ± 18.9 (30-70)

6MWD [m]

516.0 ± 49.3 (430-625)

305.0 ± 169.7 (185-425)

352.3 ± 127.1 (150-545)

291.0 ± 122.3 (0-465)

367.5 ± 88.6 (240-430)

FEV1 [%]

104.2 ± 16.6 (60.7-117.4)

89.9 ± 2.0 (88.5-91.3)

63.9 ± 10.2 (50.1-79.4)

38.2 ± 6.2 (30.2-47.3)

26.1 ± 2.8 (22.8-29.0)

VC [%]

108.5-26.4 (54.4-160.9)

107.3 ± 2.3 (105.7-108.9)

86.3 ± 12.4 (65.2-108.9)

69.2 ± 14.7 (42.6-97.7)

61.3 ± 10.6 (52.8-76.3)

FEV1/VC [%]

88.7 ± 8.6 (73.5-101.5)

73.1 ± 11.2 (65.2-81.0)

65.6 ± 12.6 (49.5-90.7)

46.8 ± 10.3 (30.0-66.3)

39.1 ± 7.5 (31.5-46.3)

BODE score

†

2.0 ± 2.8 (0.0-4.0)

2.2 ± 2.3 (0.0-6.0)

5.1 ± 2.1 (2.0-9.0)

6.3 ± 1.0 (5.0-7.0)

  1. Data are presented as mean ± SD (range), COPD: chronic obstructive pulmonary disease, M: male, F: female, BMI: body mass index, pack years: the number of cigarettes smoked per day × number of years smoked)/20 (1 pack has 20 cigarettes), 6MWD: 6-minutes walking distance, FEV1: forced expiratory volume in one second, VC: vital capacity, BODE score: index, which incorporates body mass index, airflow obstruction, dyspnoea and exercise capacity [22],% of predicted value, † not determined. Stages 1 through 4 denote severity of disease according to the Deutsche Atemwegsliga and the Deutsche Gesellschaft für Pneumologie [20], with higher number indicating greater severity.