Skip to main content

Table 3 Inflammatory outcomes after atorvastatin treatment or placebo

From: Effects of short-term treatment with atorvastatin in smokers with asthma - a randomized controlled trial

Variables Baseline 4 weeks Treatment difference,
atorvastatin minus
placebo (95% CI)
8 weeks Treatment difference,
atorvastatin minus
placebo (95% CI)
  Atorvastatin
(n = 35)
Placebo
(n = 32)
Atorvastatin
(n = 31)
Placebo
(n = 29)
  Atorvastatin & ICS
(n = 32)
Placebo & ICS
(n = 24)
 
Sputum differential
cell count &
proportion (%)
        
Total cell count (×10 4 ) 651.5
(547.0, 890.5)
620.8
(543.2, 758.8)
628.5
(533.5, 921.5)
602.0
(512.0, 791.0)
43.0
(-75.2, 161.1)
p = 0.469
607.8
(517.0, 785.5)
658.5
(563.2, 860.2)
-81.6
(-177.2,14.0)
p = 0.093
Macrophage (×10 4 )
Macrophage %
154.5
(111.5, 263.0)
38.4
(29.6, 61.3)
179.8
(87.2, 242.2)
45.1
(31.8, 58.7)
159.5
(132.0, 221.0)
45.5
(31.5, 58.9)
142.5
(81.0, 220.0)
38.5
(24.6, 54.6)
16.9
(-27.5, 61.3)
p = 0.450
4.8
(-5.9, 15.5)
p = 0.374
173.2
(126.2, 247.2)
41.4
(34.1, 54.9)
174.2
(122.8, 250.5)
44.2
(32.3, 59.0)
-3.0
(-47.6, 41.6)
p = 0.893
-0.5
(-9.6, 8.6)
p = 0.913
Neutrophil (×10 4 )
Neutrophil %
131.0
(76.0, 232.5)
37.8
(18.3, 54.2)
122.8
(56.2, 201.2
29.9
(15.0, 49.1)
136.5
(61.0, 233.5)
33.6
(18.2, 55.8)
99.0
(69.5, 299.5)
31.5
(17.6, 63.2)
-19.2
(-72.0, 33.6)
p = 0.470
-4.7
(-15.7, 6.4)
p = 0.401
151.8
(80.5, 211.5)
38.3
(23.0, 52.8)
149.0
(78.2, 229.0)
34.9
(20.7, 49.5)
-8.0
(-49.4, 33.4)
p = 0.700
2.1
(-8.0, 12.1)
p = 0.680
Eosinophil (×10 4 )
Eosinophil %
3.0
(0.5, 7.5)
0.6
(0.1, 2.4)
1.5
(0.0, 5.8)
0.4
(0.0, 1.4)
1.5
(0.0, 4.5)
0.4
(0.0, 1.0)
1.5
(0.0, 3.5)
0.3
(0.0, 1.2)
-3.2 (-8.6, 2.3)
p = 0.253
-1.0
(-2.3, 0.3)
p = 0.138
1.3
(0.3, 5.5)
0.4
(0.1, 1.1)
0.8
(0, 2.5)
0.2
(0, 0.6)
0.4
(-1.6,2.5)
p = 0.677
0.1
(-0.4, 0.5)
p = 0.798
Lymphocyte (×10 4 )
Lymphocyte %
1.5
(0.0, 3.0)
0.3
(0.0, 0.7)
0.8
(0.0, 2.8)
0.2
(0.0, 0.7)
0.5
(0.0, 3)
0.1
(0.0, 0.7)
0.5
(0.0, 1.5)
0.1
(0.0, 0.5)
0.8
(-0.2, 1.9)
p = 0.125
0.1
(-0.2, 0.4)
p = 0.425
0.8
(0.0, 2.0)
0.2
(0.0, 0.7)
1.3
(0.0, 2.5)
0.4
(0.0, 0.6)
-0.1
(-1.3, 1.1)
p = 0.865
0.1
(-0.3, 0.4)
p = 0.757
Bronchial epithelial cell (×10 4 )
Br. epithelial cell %
44.0
(26.0, 90.5)
11.5
(5.9, 26.0)
49.5
(29.0, 117.0)
12.3
(7.8, 29.2)
33.0
(18.0, 78.0)
8.4
(5.9, 17.8)
37.5
(24.0, 89.5)
9.2
(5.6, 24.8)
20.6
(-9.6, 50.9)
p = 0.177
1.6
(-5.9, 9.0)
p = 0.680
40.0
(28.0, 75.8)
11.2
(6.8, 22.2)
57.8
(39.5, 92.8)
13.3
(9.2, 22.5)
-10.3
(-32.7, 12.1)
p = 0.361
-1.3
(-7.7, 5.1)
p = 0.679
Sputum mediators         
Leukotriene B 4
(pg/ml)
103.1
(79.7, 185.4)
172.0
(106.0, 422.4)
98.4
(56.9, 215.2)
175.2
(77.0, 336.0)
-49.4
(-205.1, 106.4)
p = 0.528
104.9
(41.9, 151.5)
159.0
(81.0, 520.2)
-231.4
(-589.5, 126.6)
p = 0.200
MPO
(ng/mL)
16.5
(6.4, 39.6)
27.0
(10.6, 40.6)
16.4
(9.0, 30.5)
20.6
(10.6, 34.1)
-16.5
(-48.0, 15.0)
p = 0.298
14.8
(6.4, 34.5)
28.1
(8.9, 68.8)
-111.2
(-264.8, 42.5)
p = 0.152
Interleukin-6 (pg/ml) 139.5
(33.9, 276.5)
220.4
(70.0, 498.5)
109.3
(33.9, 351.5)
144.4
(40.3, 391.6)
-5.6
(-254.1, 243.0)
p = 0.964
147.2
(35.9, 223.0)
122.0
(34.1, 518.6)
-22.5
(-247.3, 202.3)
p = 0.841
Interleukin-8 (pg/ml) 813.1
(238.8, 3000.0)
3000.0
(426.1, 3000.0)
408.5
(179.7, 3000.0)
1686.0
(353.2, 3000.0)
-453.4
(-1071.9, 165.1)
p = 0.127
386.5
(180.7, 3000.0)
541.5
(239.4, 3000.0)
172.3
(-600.8,945.4)
p = 0.656
Interleukin-10 (pg/ml) 13.6
(1.0, 126.9)
13.0
(1.2, 80.9)
1.8
(0.3, 105.3)
15.4
(0.8, 53.4)
27.5
(-53.2, 108.2)
p = 0.497
6.1
(0.7, 72.6)
4.6
(0.7, 62.9)
-4.2
(-132.8, 124.5)
p = 0.948
Serum biomarkers         
hs-CRP (mg/L) 2.8
(1.6, 4.0)
3.6
(1.5, 6.9)
2.6
(1.6, 5.0)
2.8
(1.4, 5.6)
0.9
(-4.1, 5.9)
p = 0.718
1.9
(1.0, 4.1)
2.1
(1.0, 5.1)
0.6
(-2.8, 3.9)
p = 0.731
Interleukin-6 (pg/ml) 2.0
(0.2, 4.1)
2.6
(0.2, 30.0)
2.7
(0.2, 11.0)
1.8
(0.2, 26.0)
-9.1
(-20.8, 2.7)
p = 0.127
0.4
(0.2, 8.8)
3.1
(0.2, 21.2)
16.7
(-29.5, 62.8)
p = 0.472
  1. Abbreviations: CRP, C-reactive protein; MPO, myeloperoxisade; Mediator levels pg/ml unless otherwise indicated. Data represented as median (IQR) unless otherwise indicated.