Systematic review of the epidemiological evidence comparing lung cancer risk in smokers of mentholated and unmentholated cigarettes

Table 4 Risk of lung cancer by mentholated cigarette use among current smokers - American Health Foundation multicentre case control study [68]

Histological type of lung cancer				Years of use of mentholated cigarettes
		No. of		Never^b	1-14	15+	Ever^c
	Gender	Cases	Adjusted^a	RR	RR (CI)	RR (CI)	RR (CI)
Any	Male	588	No^d	1.00	0.98 (0.72-1.33)	0.87 (0.64-1.20)	0.92 (0.73-1.17)
			Yes	1.00	1.14 (0.82-1.59)	0.98 (0.70-1.38)	1.06 (0.82-1.37)
	Female	456	No^d	1.00	0.56 (0.38-0.83)	0.55 (0.38-0.80)	0.56 (0.42-0.75)
			Yes	1.00	0.82 (0.52-1.28)	0.76 (0.53-1.16)	0.78 (0.57-1.08)
	Combined	1044	No^d	1.00	0.79 (0.62-1.01)	0.72 (0.57-0.92)	0.76 (0.63-0.91)
			Yes^d	1.00	1.02 (0.78-1.33)	0.88 (0.68-1.14)	0.94 (0.77-1.15)
Squamous cell carcinoma	Combined	268	Yes	1.00	1.17 (0.78-1.78)	0.92 (0.60-1.42)	1.04 (0.75-1.44)
Small cell carcinoma	Combined	131	Yes	1.00	0.80 (0.43-1.48)	0.86 (0.49-1.51)	0.83 (0.53-1.30)
Large cell carcinoma	Combined	106	Yes	1.00	1.99 (0.73-5.41)	0.84 (0.27-2.61)	1.28 (0.56-2.91)
Adenocarcinoma	Combined	400	Yes	1.00	0.98 (0.68-1.42)	0.95 (0.66-1.36)	0.96 (0.73-1.28)

^a Yes = adjusted for age, race, education, cigarettes per day, inhalation, duration of smoking and body mass index. Combined gender analyses are also adjusted for gender.
^b Or less than 1 year mentholated use.
^c At least 1 year mentholated use.
^d RRs and CIs estimated as described in additional file 1: Methods for deriving RR estimates.

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