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Table 3 Characteristics of the controls and subjects with COPD in the immunohistochemical analyses of the lung

From: Ageing and long-term smoking affects KL-6 levels in the lung, induced sputum and plasma

  Non-smokers Smokers COPD
Subjects, n 7 7 14
Age, yr 65 ± 3.1 62 ± 2.6 60 ± 2.1
Sex, M/F 3/4 6/1 9/4
Pack years, yr - 24 ± 5.7 37 ± 3.8
Post-bronchodilator    
   FVC, l 4.5 ± 0.56 3.7 ± 0.25 2.4 ± 0.31**
   FEV1, l 3.5 ± 0.47 3.1 ± 0.19 1.2 ± 0.24**
   FEV1, % predicted 106 ± 4.6 88 ± 3.5* 34 ± 6.1***
   FEV1/FVC 79 ± 2.8 82 ± 2.3 45 ± 5.3**
  1. Data are shown as mean ± SEM
  2. COPD, chronic obstructive pulmonary disease; FVC, Forced vital capacity; FEV1, Forced expiratory volume in one second
  3. Two of the controls were never smokers and four of the controls had smoked for between 10-30 years but had stopped smoking at least 2 years before the study.
  4. *p < 0.05; **p < 0.01; ***p < 0.001 (vs non-smokers, Mann-Whitney U test or Chi-square test)