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Table 3 Characteristics of the controls and subjects with COPD in the immunohistochemical analyses of the lung

From: Ageing and long-term smoking affects KL-6 levels in the lung, induced sputum and plasma

 

Non-smokers

Smokers

COPD

Subjects, n

7

7

14

Age, yr

65 ± 3.1

62 ± 2.6

60 ± 2.1

Sex, M/F

3/4

6/1

9/4

Pack years, yr

- †

24 ± 5.7

37 ± 3.8

Post-bronchodilator

   

   FVC, l

4.5 ± 0.56

3.7 ± 0.25

2.4 ± 0.31**

   FEV1, l

3.5 ± 0.47

3.1 ± 0.19

1.2 ± 0.24**

   FEV1, % predicted

106 ± 4.6

88 ± 3.5*

34 ± 6.1***

   FEV1/FVC

79 ± 2.8

82 ± 2.3

45 ± 5.3**

  1. Data are shown as mean ± SEM
  2. COPD, chronic obstructive pulmonary disease; FVC, Forced vital capacity; FEV1, Forced expiratory volume in one second
  3. † Two of the controls were never smokers and four of the controls had smoked for between 10-30 years but had stopped smoking at least 2 years before the study.
  4. *p < 0.05; **p < 0.01; ***p < 0.001 (vs non-smokers, Mann-Whitney U test or Chi-square test)