Figure 2

Morphometric assessment of the effects of antagomir treatment. Quantification of (A) profile density of intraepithelial eosinophils (B) profile density of chronic inflammatory cells in the lamina propria (C) thickness of subepithelial collagenisation (all assessed in the trachea) and (D) grade of mucous cell change (assessed in intrapulmonary airways) after 6 weeks of chronic challenge and antagomir treatment. Values are expressed as mean ± SEM (A-C) or median ± interquartile range (D); 8 animals were assessed per group. Significant differences compared to naïve controls are shown as * (p < 0.05), ** (p < 0.01), *** (p < 0.001); significant difference compared to mice treated with ant-scrambled is shown as # (p < 0.05).