Table 2 Difference versus placebo in the change in QTcF interval from baseline on Day 14
Time post- dose | Indacaterol | Placebo/moxifloxacin vs placebo | ||
|---|---|---|---|---|
150 μg vs placebo | 300 μg vs placebo | 600 μg vs placebo | ||
Mean (90% confidence intervals), in ms | ||||
10 min | 1.62 (-0.34, 3.57) | 1.26 (-0.64, 3.16) | 1.56 (-0.83, 3.94) | 1.84 (-1.32, 5.01) |
20 min | 2.23 (0.34, 4.12) | 2.24 (0.45, 4.03) | 2.84 (0.72, 4.95) | 3.74 (0.97, 6.51) |
40 min | 2.12 (0.21, 4.03) | 1.54 (-0.41, 3.49) | 1.40 (-0.96, 3.76) | 8.25 (5.04, 11.47) |
1 h | 0.89 (-1.12, 2.89) | 1.05 (-0.99, 3.09) | 0.70 (-1.72, 3.12) | 10.76 (7.60, 13.93) |
2 h | 2.66 (0.55, 4.77) | 2.98 (1.02, 4.93) | 2.18 (-0.25, 4.61) | 13.90 (10.58, 17.22) |
3 h | 0.48 (-1.53, 2.50) | 1.06 (-0.91, 3.03) | 2.14 (-0.19, 4.48) | 11.12 (8.08, 14.15) |
4 h | 0.36 (-1.82, 2.53) | 0.29 (-1.76, 2.33) | 1.17 (-1.26, 3.59) | 11.91 (8.57, 15.24) |
6 h | 0.46 (-1.70, 2.62) | 1.21 (-0.64, 3.05) | 3.34 (0.86, 5.82) | 9.25 (5.93, 12.57) |
12 h | 0.44 (-1.69, 2.57) | -1.24 (-3.26, 0.79) | -1.62 (-4.23, 0.98) | 4.24 (0.82, 7.67) |
24 h | 1.88 (0.12, 3.64) | 0.67 (-1.15, 2.49) | -0.08 (-2.27, 2.11) | 7.77 (4.73, 10.82) |