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Table 1 Rates of antibiotics dispensed per year of age, by age of asthma diagnosis and rate ratios compared to non-asthmatics by age 6 (rates standardized for year 2000)

From: Antibiotic consumption in children prior to diagnosis of asthma

 

No asthma by age 6 (n = 96,496)

Age at asthma index date

  

Age 2 (n = 2,791)

Age 3 (n = 2,572)

Age 4 (n = 2,238)

Age 5 (n = 2,039)

Age, years

Rate of ABX per 100 PY

Rate of ABX per 100 PY

RR (95% CI)*

Rate of ABX per 100 PY

RR (95% CI)*

Rate of ABX per 100 PY

RR (95% CI)*

Rate of ABX per 100 PY

RR (95% CI)*

0

84.6

123.9

1.47 (1.40-1.53)

118.5

1.40 (1.34-1.47)

110.8

1.31 (1.25-1.38)

108.3

1.28 (1.22-1.35)

1

118.8

190.1

1.60 (1.54-1.66)

173.4

1.46 (1.40-1.52)

165.0

1.39 (1.33-1.45)

156.4

1.32 (1.26-1.46)

2

90.1

213.0

2.36 (2.28-2.45)

149.0

1.65 (1.58-1.73)

140.2

1.56 (1.48-1.63)

124.9

1.39 (1.32-1.46)

3

89.0

170.0

1.91 (1.84-1.99)

207.5

2.33 (2.24-2.42)

156.8

1.76 (1.68-1.84)

136.9

1.54 (1.46-1.62)

4

85.7

148.1

1.73 (1.65-1.80)

162.1

1.89 (1.81-1.97)

197.0

2.30 (2.20-2.40)

141.9

1.66 (1.57-1.74)

5

85.8

143.3

1.67 (1.60-1.75)

147.2

1.72 (1.64-1.79)

164.0

1.91 (1.83-2.00)

198.1

2.31 (2.21-2.41)

Before age 6

91.5

162.5

1.77 (1.75-1.80)

156.7

1.72 (1.69-1.74)

152.2

1.66 (1.63-1.69)

141.0

1.55 (1.51-1.58)

  1. * compared to rate of ABX in those without asthma by age 6 and adjusted for calendar year
  2. Abbreviations: ABX - antibiotics; PY - person years; RR - rate ratio