Figure 1

Changes in body mass and lung microstructure after intratracheal bleomycin to a sensitive (C57BL/6) and a resistant (Balb/c) mouse strain. C57BL/6 (n = 38) and Balb/c (n = 32) mice received single doses of 2 mg/kg intratracheal bleomycin or saline control (injection volume = 50 μl). A. Both C57BL/6and Balb/c developed early weight loss after bleomycin (but not saline). Only C57BL/6mice displayed persistent cachexia after bleomycin. B. Representative histologic images of lungs at early (7 days after intratracheal bleomycin), and late (21 days after intratracheal bleomycin, respectively) time-points. (Scale bar = 200 μm). (***P < .001 compared with C57BL/6 N/S; *P < .05 compared with Balb/c N/S). Data points, mean; bars, SD. Solid Circles: C57BL/6-Saline; Open circles: Balb/c-saline; Solid triangles: C57BL/6-bleomycin; Open triangles: Balb/c-bleomycin).