Figure 3

Mechanical parameters of lung injury and fibrosis induced by bleomycin administration to resistant (Balb/c) and sensitive (C57BL/6) mouse strains. Mice were treated with bleomycin (black columns) or saline (white columns) as in Fig. 1 and lung function was determined using the forced oscillation technique and the constant phase model at early and late time-points. *P < 0.05, **P < 0.01, and ***P < 0.001 compared with saline-treated controls. Columns, mean; bars, SD. R _N , airway resistance; H, lung tissue elastance; G, lung tissue damping; η, hysteresivity.