Figure 7
From: The asthma candidate gene NPSR1 mediates isoform specific downstream signalling
Phosphorylation site-directed mutagenesis of NPSR1-A and NPSR1-B C-termini. Relative CGA mRNA expression after 1, 6 and 24 h NPS stimulation of HEK-293 cells overexpressing NPSR1-A or -B containing phosphorylation site mutations in the C-termini. From left to right: NPSR1-A,-AΔ5p, -AΔ3p, -AΔ2p, NPSRI-B and -BΔ2p. Expression shown as means relative to an NPS stimulated empty vector control ± SEM.