Table 2 Mean values at baseline and post-treatment for spirometric and other parameters
Placebo (n = 208) | Formoterol 4.5 μg (n = 206) | Formoterol 9 μg (n = 199) | |
|---|---|---|---|
60-min post-dose FEV1, L | |||
Baseline | 1.23 | 1.18 | 1.16 |
Post-treatment | 1.25 | 1.33 | 1.31 |
Ratio to baseline (%) | 101.3 | 112.6 | 113.4 |
Pre-dose FEV1, L | |||
Baseline | 1.23 | 1.18 | 1.16 |
Post-treatment | 1.24 | 1.23 | 1.21 |
Ratio to baseline (%) | 99.8 | 104.5 | 104.7 |
5-min post-dose FEV1, L | |||
Baseline | 1.23 | 1.18 | 1.16 |
Post-treatment | 1.24 | 1.30 | 1.28 |
Ratio to baseline (%) | 101.3 | 110.2 | 110.2 |
60-min post-dose FVC, L | |||
Baseline | 2.77 | 2.71 | 2.61 |
Post-treatment | 2.82 | 2.98 | 2.87 |
Ratio to baseline (%) | 102.1 | 109.7 | 109.9 |
Pre-dose FVC, L | |||
Baseline | 2.77 | 2.71 | 2.61 |
Post-treatment | 2.80 | 2.81 | 2.70 |
Ratio to baseline (%) | 100.7 | 103.6 | 103.4 |
5-min post-dose FVC, L | |||
Baseline | 2.77 | 2.71 | 2.61 |
Post-treatment | 2.80 | 2.94 | 2.84 |
Ratio to baseline (%) | 101.6 | 108.5 | 108.9 |
Morning PEF, L/min | |||
Run-in | 223.8 | 211.9 | 215.0 |
Treatment | 227.6 | 228.1 | 233.5 |
Change from run-in | 3.6 | 16.3 | 18.3 |
Evening PEF, L/min | |||
Run-in | 233.8 | 221.4 | 221.9 |
Treatment | 236.5 | 234.6 | 237.5 |
Change from run-in | 2.4 | 13.2 | 15.8 |
Night-time awakening, score/day | |||
Run-in | 0.73 | 0.66 | 0.83 |
Treatment | 0.68 | 0.53 | 0.66 |
Change from run-in | -0.05 | -0.13 | -0.17 |
Breathlessness, score/day | |||
Run-in | 1.65 | 1.51 | 1.72 |
Treatment | 1.38 | 1.11 | 1.28 |
Change from run-in | -0.26 | -0.41 | -0.45 |
Cough, score/day | |||
Run-in | 1.46 | 1.44 | 1.63 |
Treatment | 1.26 | 1.11 | 1.21 |
Change from run-in | -0.20 | -0.33 | -0.41 |
Total symptom score | |||
Run-in | 3.84 | 3.61 | 4.19 |
Treatment | 3.32 | 2.75 | 3.14 |
Change from run-in | -0.51 | -0.86 | -1.04 |
Use of salbutamol, inhalations/day | |||
Run-in | 1.86 | 2.09 | 2.40 |
Treatment | 1.63 | 1.52 | 1.50 |
Change from run-in | -0.23 | -0.60 | -0.97 |
SGRQ total score | |||
Baseline | 44.9 | 43.4 | 44.0 |
Last available score | 42.9 | 38.2 | 38.2 |
Change from baseline | -2.0 | -5.5 | -6.4 |