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Table 2 Mean values at baseline and post-treatment for spirometric and other parameters

From: Efficacy and safety of inhaled formoterol 4.5 and 9 μg twice daily in Japanese and European COPD patients: Phase III study results

  Placebo
(n = 208)
Formoterol 4.5 μg
(n = 206)
Formoterol 9 μg
(n = 199)
60-min post-dose FEV1, L    
   Baseline 1.23 1.18 1.16
   Post-treatment 1.25 1.33 1.31
   Ratio to baseline (%) 101.3 112.6 113.4
Pre-dose FEV1, L    
   Baseline 1.23 1.18 1.16
   Post-treatment 1.24 1.23 1.21
   Ratio to baseline (%) 99.8 104.5 104.7
5-min post-dose FEV1, L    
   Baseline 1.23 1.18 1.16
   Post-treatment 1.24 1.30 1.28
   Ratio to baseline (%) 101.3 110.2 110.2
60-min post-dose FVC, L    
   Baseline 2.77 2.71 2.61
   Post-treatment 2.82 2.98 2.87
   Ratio to baseline (%) 102.1 109.7 109.9
Pre-dose FVC, L    
   Baseline 2.77 2.71 2.61
   Post-treatment 2.80 2.81 2.70
   Ratio to baseline (%) 100.7 103.6 103.4
5-min post-dose FVC, L    
   Baseline 2.77 2.71 2.61
   Post-treatment 2.80 2.94 2.84
   Ratio to baseline (%) 101.6 108.5 108.9
Morning PEF, L/min    
   Run-in 223.8 211.9 215.0
   Treatment 227.6 228.1 233.5
   Change from run-in 3.6 16.3 18.3
Evening PEF, L/min    
   Run-in 233.8 221.4 221.9
   Treatment 236.5 234.6 237.5
   Change from run-in 2.4 13.2 15.8
Night-time awakening, score/day    
   Run-in 0.73 0.66 0.83
   Treatment 0.68 0.53 0.66
   Change from run-in -0.05 -0.13 -0.17
Breathlessness, score/day    
   Run-in 1.65 1.51 1.72
   Treatment 1.38 1.11 1.28
   Change from run-in -0.26 -0.41 -0.45
Cough, score/day    
   Run-in 1.46 1.44 1.63
   Treatment 1.26 1.11 1.21
   Change from run-in -0.20 -0.33 -0.41
Total symptom score    
   Run-in 3.84 3.61 4.19
   Treatment 3.32 2.75 3.14
   Change from run-in -0.51 -0.86 -1.04
Use of salbutamol, inhalations/day    
   Run-in 1.86 2.09 2.40
   Treatment 1.63 1.52 1.50
   Change from run-in -0.23 -0.60 -0.97
SGRQ total score    
   Baseline 44.9 43.4 44.0
   Last available score 42.9 38.2 38.2
   Change from baseline -2.0 -5.5 -6.4