Asthma control cost-utility randomized trial evaluation (ACCURATE): the goals of asthma treatment

BMC Pulmonary Medicine

Table 3 Treatment strategy algorithms

	Levels of asthma control
Strategy	Strictly controlled	Sufficiently controlled	Uncontrolled
STRICT-strategy	- 3 mo: no change	step-up: treatment choice	step-up: treatment choice
	- > 3 mo: step-down
SUFF-strategy	step-down	no change	step-up: treatment choice
FeNO strategy
- Low FeNO level	step-down	- 3 mo: no change/change within current step to LABA	step-up: LABA
		- > 3 mo: step-down ICS
- Intermediate FeNO level	no change	step-up: treatment choice	step-up: treatment choice
- High FeNO level	step-up/change within current step to ICS	step-up: 1 × ICS	step-up: 2 × ICS*

STRICT-strategy = strictly controlled strategy; SUFF-strategy = sufficiently controlled strategy. A raised FeNO level is indicative of eosinophilic airway inflammation; ICS = inhaled corticosteroids; LABA = long-acting ß₂-agonist. *until a maximum high dose of ICS is reached

ISSN: 1471-2466