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Table 3 Treatment strategy algorithms

From: Asthma control cost-utility randomized trial evaluation (ACCURATE): the goals of asthma treatment

  Levels of asthma control  
Strategy Strictly controlled Sufficiently controlled Uncontrolled
STRICT-strategy - 3 mo: no change step-up: treatment choice step-up: treatment choice
  - > 3 mo: step-down   
SUFF-strategy step-down no change step-up: treatment choice
FeNO strategy    
- Low FeNO level step-down - 3 mo: no change/change within current step to LABA step-up: LABA
   - > 3 mo: step-down ICS  
- Intermediate FeNO level no change step-up: treatment choice step-up: treatment choice
- High FeNO level step-up/change within current step to ICS step-up: 1 × ICS step-up: 2 × ICS*
  1. STRICT-strategy = strictly controlled strategy; SUFF-strategy = sufficiently controlled strategy. A raised FeNO level is indicative of eosinophilic airway inflammation; ICS = inhaled corticosteroids; LABA = long-acting ß2-agonist. *until a maximum high dose of ICS is reached