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Table 3 Diagnostic validity of self-reported methods to detect non adherent patients with the prescribed treatment.

From: Is it possible to diagnose the therapeutic adherence of patients with COPD in clinical practice? A cohort study

  VISIT 1 VISIT 2 VISIT 3
Non adherence (reference method) 31.9% 20% 16%
Morisky-Green Test    
Non adherence 39.2% 32.4% 30.9%
Sensitivity 53.33% (38.76-68) 66.66%(46.66-86.66) 33.33%(10.3-56.3)
Specificity 67.34% (58.06-76.62) 76.19% (67-85.3) 69.62%(59.6-79.6)
Positive Predictive Value 42.86% 41.17% 17.24%
Negative Predictive Value 75.86% 90.14% 84.61%
Positive Likelihood Ratio 1.66 2.79 1.09
Negative Likelihood Ratio 0.69 0.43 0.95
Batalla Test    
Non adherence 53.1% 38.1% 35.1%
Sensitivity 68.88%(55.36-82.4) 71.43%(52.1-90) 46.66%(21.6-71.66)
Specificity 55.1%(45.3-64.9) 70.23%(60.5-80) 67.09%(57.09-77.09)
Positive Predictive Value 40.79% 37.5% 21.21%
Negative Predictive Value 85.07% 90.77% 86.88%
Positive Likelihood Ratio 1.53 2.38 1.41
Negative Likelihood Ratio 0.56 0.4 0.79
MGT-BT 1- (non.adherent at least by one of two methods)    
Non adherence 71.3% 56.2% 57.4%
Sensitivity 84.44%(74-95) 90.47%(78.47-100) 66.66%(56.66-76.66)
Specificity 34.69%(25.3-44.1) 52.38%(42.38-62.38) 44.3%(34.3-54.3)
Positive Predictive Value 37.25% 32.2% 18.51%
Negative Predictive Value 82.92% 95.6% 87.5%
Positive Likelihood Ratio 1.29 1.89 1.19
Negative Likelihood Ratio 0.45 0.18 0.75
MGT-BT 2- (non-adherent by the two methods)    
Non adherence 21% 14.3% 8.5%
Sensitivity 37.77%(23.6-52) 47.62%(26.6-68.6) 13.3%(0-30)
Specificity 86.73%(80-93.4) 94.04% (89-99) 92.49%(86.6-98.2)
Positive Predictive Value 56.66% 66.66% 25%
Negative Predictive Value 82.52% 87.77% 84.88%
Positive Likelihood Ratio 2.84 7.98 1.77
Negative Likelihood Ratio 0.71 0.55 0.93
  1. Morinsky-Green Test : MGT; Batalla Test:BT; Sensitivity : S ; Specificity : E ; Positive Probability Ratio: PPR.