Table 3 Diagnostic validity of self-reported methods to detect non adherent patients with the prescribed treatment.
VISIT 1 | VISIT 2 | VISIT 3 | |
|---|---|---|---|
Non adherence (reference method) | 31.9% | 20% | 16% |
Morisky-Green Test | |||
Non adherence | 39.2% | 32.4% | 30.9% |
Sensitivity | 53.33% (38.76-68) | 66.66%(46.66-86.66) | 33.33%(10.3-56.3) |
Specificity | 67.34% (58.06-76.62) | 76.19% (67-85.3) | 69.62%(59.6-79.6) |
Positive Predictive Value | 42.86% | 41.17% | 17.24% |
Negative Predictive Value | 75.86% | 90.14% | 84.61% |
Positive Likelihood Ratio | 1.66 | 2.79 | 1.09 |
Negative Likelihood Ratio | 0.69 | 0.43 | 0.95 |
Batalla Test | |||
Non adherence | 53.1% | 38.1% | 35.1% |
Sensitivity | 68.88%(55.36-82.4) | 71.43%(52.1-90) | 46.66%(21.6-71.66) |
Specificity | 55.1%(45.3-64.9) | 70.23%(60.5-80) | 67.09%(57.09-77.09) |
Positive Predictive Value | 40.79% | 37.5% | 21.21% |
Negative Predictive Value | 85.07% | 90.77% | 86.88% |
Positive Likelihood Ratio | 1.53 | 2.38 | 1.41 |
Negative Likelihood Ratio | 0.56 | 0.4 | 0.79 |
MGT-BT 1- (non.adherent at least by one of two methods) | |||
Non adherence | 71.3% | 56.2% | 57.4% |
Sensitivity | 84.44%(74-95) | 90.47%(78.47-100) | 66.66%(56.66-76.66) |
Specificity | 34.69%(25.3-44.1) | 52.38%(42.38-62.38) | 44.3%(34.3-54.3) |
Positive Predictive Value | 37.25% | 32.2% | 18.51% |
Negative Predictive Value | 82.92% | 95.6% | 87.5% |
Positive Likelihood Ratio | 1.29 | 1.89 | 1.19 |
Negative Likelihood Ratio | 0.45 | 0.18 | 0.75 |
MGT-BT 2- (non-adherent by the two methods) | |||
Non adherence | 21% | 14.3% | 8.5% |
Sensitivity | 37.77%(23.6-52) | 47.62%(26.6-68.6) | 13.3%(0-30) |
Specificity | 86.73%(80-93.4) | 94.04% (89-99) | 92.49%(86.6-98.2) |
Positive Predictive Value | 56.66% | 66.66% | 25% |
Negative Predictive Value | 82.52% | 87.77% | 84.88% |
Positive Likelihood Ratio | 2.84 | 7.98 | 1.77 |
Negative Likelihood Ratio | 0.71 | 0.55 | 0.93 |