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Table 2 Efficacy endpoints: FENO, PC20 AMP, and FEV1.

From: Rapid effects of extrafine beclomethasone dipropionate/formoterol fixed combination inhaler on airway inflammation and bronchoconstriction in asthma: a randomised controlled trial

FENO (ppb) - Day 3, 4 hours LS Mean 95% CI
   High dose 50.5 43.8, 57.3
   Low dose 58.9 52.2, 65.7
   Placebo 71.1 64.4, 77.8
FE NO (ppb) - Day 3, 2 hours LS Mean 95% CI
   High dose 51.8 44.5, 59.2
   Low dose 60.2 53.0, 67.5
   Placebo 74.4 67.2, 81.5
AMP PC 20 (mg/mL) - Day 3, 4 hours Log2 LS Mean Log2 95% CI
   High dose 7.1 5.9, 8.2
   Low dose 6.0 4.9, 7.1
   Placebo 2.3 1.2, 3.4
FEV 1 (L) - AUC 0-4 h Day 1 LS Mean 95% CI
   High dose 3.6 3.5, 3.6
   Low dose 3.6 3.5, 3.6
   Placebo 3.4 3.3, 3.4
  1. LS Mean = least squares mean; CI = confidence interval; FENO = Fractional exhaled nitric oxide; AMP PC20 = AMP challenge provocative concentration causing a 20% fall in FEV1; FEV1 = forced expiratory volume in one second.
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BMC Pulmonary Medicine

ISSN: 1471-2466

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