FENO (ppb) - Day 3, 4 hours
|
LS Mean
|
95% CI
|
P-value
|
---|
High dose - placebo
|
-20.5
|
-28.5, -12.6
|
< 0.0001
|
Low dose - placebo
|
-12.1
|
-20.1, -4.1
|
0.0043
|
High dose - low dose
|
-8.4
|
-16.6, -0.3
|
0.0423
|
FE
NO
(ppb) - Day 3, 2 hours
|
LS Mean
|
95% CI
|
P-value
|
High dose - placebo
|
-22.5
|
-30.1, -15.0
|
< 0.0001
|
Low dose - placebo
|
-14.1
|
-21.7, -6.6
|
0.0006
|
High dose - low dose
|
-8.4
|
-16.2, -0.7
|
0.0342
|
AMP PC
20
(mg/mL) - Day 3, 4 hours
|
Log2 LS Mean
|
Log2 95% CI
|
P-value
|
High dose - placebo
|
4.8
|
3.9, 5.6
|
< 0.0001
|
Low dose - placebo
|
3.7
|
2.8, 4.6
|
< 0.0001
|
High dose - low dose
|
1.0
|
0.2, 1.9
|
0.0185
|
FEV
1
(L) - AUC
0-4 h
Day 1
|
LS Mean
|
95% CI
|
P-value
|
High dose - placebo
|
0.2
|
0.1, 0.3
|
0.0001
|
Low dose - placebo
|
0.2
|
0.1, 0.3
|
0.0001
|
High dose - low dose
|
0.0
|
-0.1, 0.1
|
0.9832
|
- LS Mean = least squares mean; CI = confidence interval; FENO = Fractional exhaled nitric oxide; AMP PC20 = AMP challenge provocative concentration causing a 20% fall in FEV1; FEV1 = forced expiratory volume in one second.