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Table 3 Statistical comparisons of efficacy endpoints.

From: Rapid effects of extrafine beclomethasone dipropionate/formoterol fixed combination inhaler on airway inflammation and bronchoconstriction in asthma: a randomised controlled trial

FENO (ppb) - Day 3, 4 hours LS Mean 95% CI P-value
   High dose - placebo -20.5 -28.5, -12.6 < 0.0001
   Low dose - placebo -12.1 -20.1, -4.1 0.0043
   High dose - low dose -8.4 -16.6, -0.3 0.0423
FE NO (ppb) - Day 3, 2 hours LS Mean 95% CI P-value
   High dose - placebo -22.5 -30.1, -15.0 < 0.0001
   Low dose - placebo -14.1 -21.7, -6.6 0.0006
   High dose - low dose -8.4 -16.2, -0.7 0.0342
AMP PC 20 (mg/mL) - Day 3, 4 hours Log2 LS Mean Log2 95% CI P-value
   High dose - placebo 4.8 3.9, 5.6 < 0.0001
   Low dose - placebo 3.7 2.8, 4.6 < 0.0001
   High dose - low dose 1.0 0.2, 1.9 0.0185
FEV 1 (L) - AUC 0-4 h Day 1 LS Mean 95% CI P-value
   High dose - placebo 0.2 0.1, 0.3 0.0001
   Low dose - placebo 0.2 0.1, 0.3 0.0001
   High dose - low dose 0.0 -0.1, 0.1 0.9832
  1. LS Mean = least squares mean; CI = confidence interval; FENO = Fractional exhaled nitric oxide; AMP PC20 = AMP challenge provocative concentration causing a 20% fall in FEV1; FEV1 = forced expiratory volume in one second.
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BMC Pulmonary Medicine

ISSN: 1471-2466

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