Rapid effects of extrafine beclomethasone dipropionate/formoterol fixed combination inhaler on airway inflammation and bronchoconstriction in asthma: a randomised controlled trial

Table 3 Statistical comparisons of efficacy endpoints.

FE_NO (ppb) - Day 3, 4 hours	LS Mean	95% CI	P-value
High dose - placebo	-20.5	-28.5, -12.6	< 0.0001
Low dose - placebo	-12.1	-20.1, -4.1	0.0043
High dose - low dose	-8.4	-16.6, -0.3	0.0423
FE _NO (ppb) - Day 3, 2 hours	LS Mean	95% CI	P-value
High dose - placebo	-22.5	-30.1, -15.0	< 0.0001
Low dose - placebo	-14.1	-21.7, -6.6	0.0006
High dose - low dose	-8.4	-16.2, -0.7	0.0342
AMP PC ₂₀ (mg/mL) - Day 3, 4 hours	Log2 LS Mean	Log2 95% CI	P-value
High dose - placebo	4.8	3.9, 5.6	< 0.0001
Low dose - placebo	3.7	2.8, 4.6	< 0.0001
High dose - low dose	1.0	0.2, 1.9	0.0185
FEV ₁ (L) - AUC _{0-4 h} Day 1	LS Mean	95% CI	P-value
High dose - placebo	0.2	0.1, 0.3	0.0001
Low dose - placebo	0.2	0.1, 0.3	0.0001
High dose - low dose	0.0	-0.1, 0.1	0.9832

LS Mean = least squares mean; CI = confidence interval; FE_NO = Fractional exhaled nitric oxide; AMP PC₂₀ = AMP challenge provocative concentration causing a 20% fall in FEV₁; FEV₁ = forced expiratory volume in one second.

ISSN: 1471-2466