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Table 6 Sensitivity analysis for non-smokers: mean (SE) postbronchodilator FEV1 decline in ml/year in the three categories* based on alternative LLN prediction equations for the base case population

From: Lung function decline in relation to diagnostic criteria for airflow obstruction in respiratory symptomatic subjects

   Category*      
   Non-obstructed Discordant Obstructed p-value
   (LLN-Fixed-) (LLN-Fixed+) (LLN+Fixed+) Overall difference
between categories
LLN-Fixed+ versus
LLN-Fixed-
LLN-Fixed+ versus
LLN+Fixed+
Swanney [6], 2008 FEV1 decline -15 (1) -17 (4) -36 (4) < 0.001 0.624 < 0.001
  n 1,828 251 237    
ECSC [25], 1993 FEV1 decline -15 (1) -15 (8) -28 (3) < 0.001 0.975 0.132
  n 1,831 71 426    
Kuster [28], 2008 FEV1 decline -15 (1) -8 (12) -26 (3) < 0.001 0.076 0.009
  n 1,814 28 532    
Falaschetti [26], 2004 FEV1 decline -15 (1) -22 (8) -27 (3) < 0.001 0.376 0.521
  n 1,785 71 488    
Brandli [27], 2000 FEV1 decline -15 (1) -17 (6) -31 (3) < 0.001 0.746 0.036
  n 1,828 125 349    
Hankinson [29], 1999 FEV1 decline -15 (1) -7 (10) -26 (3) < 0.001 0.424 0.061
  n 1,816 46 482    
  1. ECSC: European Community for Steel and Coal; FEV1: forced expiratory volume in 1 s; LLN: lower limit of normal; SD: standard deviation
  2. * based on reference equations for LLN as indicated in first column
  3. † between group differences were analyzed using random coefficient regression models with random intercept and random slope; adjustment for inhaled corticosteroid use
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