Ā | Cell lysate | Supernatant | ||||
---|---|---|---|---|---|---|
Ā | WT | A116D | P | WT | A116D | P |
Total phospholipids (nmol/mg protein) | 152.80 Ā± 9.6 | 126.50 Ā± 10.6 | 0.0334 | 20.57 Ā± 3.8 | 12.90 Ā± 6.2 | 0.0259 |
Phospholipid classes (% of total PL) | Ā | Ā | Ā | Ā | Ā | |
Phosphatidylcholine | 57.80 Ā± 1.0 | 52.80 Ā± 0.2 | < 0.001 | 44.70 Ā± 0.1 | 38.73 Ā± 0.6 | < 0.001 |
Lyso-Phosphatidylcholine | 0.60 Ā± 0.1 | 0.90 Ā± 0.2 | 0.0171 | 5.90 Ā± 0.4 | 16.78 Ā± 1.3 | 0.001 |
Phosphatidylglycerol | 0.30 Ā± 0.0 | 0.30 Ā± 0.0 | ns | 0.20 Ā± 0.1 | 0.10 Ā± 0.1 | ns |
Sphingomyelin | 6.20 Ā± 0.3 | 6.90 Ā± 0.3 | 0.0061 | 8.03 Ā± 0.2 | 11.14 Ā± 0.2 | < 0.0001 |
Ceramide | 1.80 Ā± 0.1 | 1.60 Ā± 0.1 | 0.0133 | 3.30 Ā± 0.3 | 2.15 Ā± 0.2 | 0.0034 |
Glucosyl-Ceramide | 0.10 Ā± 0.0 | 0.20 Ā± 0.0 | ns | 0.08 Ā± 0.0 | 0.09 Ā± 0.0 | ns |
Phosphatidylethanolamine | 11.20 Ā± 0.5 | 14.50 Ā± 0.1 | < 0.001 | 6.54 Ā± 0.2 | 6.53 Ā± 0.1 | ns |
Phosphatidylserine | 6.50 Ā± 0.1 | 7.70 Ā± 0.3 | < 0.001 | 11.71 Ā± 0.8 | 8.57 Ā± 0.1 | 0.0028 |