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Table 2 Relationship between FEV1 percent predicted and biomarkers in CF subjects per 1 log increase in the biomarkers (n = 58)

From: The relationship of systemic inflammation to prior hospitalization in adult patients with cystic fibrosis

  Unadjusted Adjusted* Standardized Beta-Coefficient
(per 1 SD increase in the levels of biomarker)
Biomarker β ± SE P-value β ± SE P-value  
CRP, mg/L -10.61 ± 2.65 < 0.01 -7.04 ± 1.98 < 0.01 -0.3134
IL-6, pg/mL -10.72 ± 3.11 < 0.01 -5.53 ± 2.66 0.04 -0.2159
IL-1β, pg/mL -6.97 ± 3.36 0.04 -4.65 ± 2.67 < 0.01 -0.1784
SP-D, μg/mL -17.70 ± 7.95 0.03 -9.83 ± 5.93 0.10 -0.1584
CCL18, pg/mL -6.33 ± 5.93 0.29 -3.01 ± 4.23 0.48 -0.0672
GzmB, pg/mL 4.09 ± 2.27 0.08 -0.33 ± 1.89 0.86 -0.0187
LPS, pg/mL 1.07 ± 7.44 0.89 13.30 ± 5.41 0.02 0.0239
sCD14, μg/mL 1.88 ± 9.67 0.85 -10.26 ± 6.96 0.15 -0.1414
LBP, μg/mL -22.28 ± 6.63 < 0.01 -16.02 ± 4.74 < 0.01 -0.2946
  1. * Adjusted for age, pseudomonal status, and history of hospitalization, which were significantly related to reduced lung function