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Table 3 Geometric means (and interquartile ranges) of biomarkers in CF patients who were and were not previously hospitalized

From: The relationship of systemic inflammation to prior hospitalization in adult patients with cystic fibrosis

Biomarker Total
(n = 58)*
Previously hospitalized
(n = 21)*
Not previously hospitalized
(n = 37)*
P-value Adjusted P-value c-statistics
CRP, μg/mL 3.0
(1.5, 6.1)
3.5
(2.0, 8.0)
2.8
(1.3, 5.6)
0.50 0.51 0.795
IL-6, pg/mL 2.2
(1.1, 4.2)
3.6
(2.8, 5.8)
1.7
(1.0, 3.1)
< 0.01 0.07 0.837
IL-1β, pg/mL 0.16
(0.06, 0.29)
0.19
(0.06, 0.50)
0.10
(0.06, 0.20)
< 0.01 0.06 0.828
SP-D, ng/mL 84.3
(64.0, 112.3)
87.5
(75.3, 106.1)
82.6
(63.7, 113.2)
0.60 0.26 0.804
CCL18, ng/mL 59.5
(41.4, 75.3)
60.1
(38.7, 73.5)
59.2
(44.5, 75.9)
0.92 0.92 0.797
GzmB, pg/ml 109.2
(25.5, 389.8)
90.7
(25.4, 384.9)
121.2
(26.2, 389.8)
0.46 0.83 0.792
LPS, ng/mL 1.1
(0.9, 1.3)
1.3
(1.0, 1.4)
1.0
(0.8, 1.3)
0.01 0.04 0.841
sCD14, μg/mL 1.1
(0.9, 1.3)
1.1
(1.0, 1.3)
1.1
(0.8, 1.3)
0.89 0.49 0.789
LBP, μg/mL 27.6
(22.0, 39.9)
30.8
(23.7, 41.2)
25.9
(18.8, 35.7)
0.17 0.79 0.781
  1. * Data are presented as geometric mean (25th, 75th percentile)
  2. Adjusted for FEV1% predicted, BMI, and pseudomonal status, which collectively had a c-statistic (or area under the curve) value of 0.797