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Table 1 Respiratory, metabolic and socio-demographic characteristics, The Whyalla Intergenerational Study of Health (WISH, 2008–2009)

From: Abdominal adiposity and obstructive airway disease: testing insulin resistance and sleep disordered breathing mechanisms

  

Current Doctor-Diagnosed Asthma

 

Asthma x spirometry quality

  

No (n = 575)

Yes (n = 151)

F(df) or Chi2(df)

P

F(df) or Chi2(df)

P

Completion/

No test

77

21

    

acceptability of spirometry

Unacceptable

51

15

    
 

Acceptable

447

115

    

Outcomes, asthma symptoms

       

CASS, range 0-8

No test

3.62 (3.26, 3.99)

5.33 (4.64, 6.27)

F(5,711) = 19.26

<0.001

F(2,711) = 1.16

0.32

 

Unacceptable

3.28 (2.83, 3.72)

5.23 (4.35, 6.11)

    
 

Acceptable

3.28 (3.13, 3.43)

4.56 (4.26, 4.86)

    

log CASS

No test

1.16 (1.05, 1.27)

1.63 (1.41, 1.84)

F(5,711) = 14.33

<0.001

F(2,711) = 0.55

0.58

 

Unacceptable

1.09 (0.95, 1.22)

1.54 (1.27, 1.82)

    
 

Acceptable

1.07 (1.03, 1.12)

1.42 (1.33, 1.51)

    

Outcomes, spirometry

       

(acceptable tests only)

       

FEV1 reversibility, L

 

0.11 (0.09, 0.12)

0.12 (0.09, 0.14)

F(1, 538) = 0.22

0.64

  

FEV1 reversibility,%

 

3.88 (3.27, 4.49)

5.03 (3.83, 6.24)

F(1, 538) = 2.80

0.10

  

post FEV1, L

 

3.01 (2.93, 3.10)

2.76 (2.60, 2.92)

F(1, 538) = 7.62

<0.01

  

post FVC, L

 

3.80 (3.70, 3.90)

3.64 (3.44, 3.83)

F(1, 523) = 2.02

0.16

  

post FEV1/FVC,%

 

79.46 (78.73, 80.19)

76.14 (74.70, 77.57)

F(1, 523) = 16.34

<0.001

  

post PEF, L/s

 

7.83 (7.62, 8.03)

7.23 (6.83, 7.63)

F(1, 538) = 6.80

<0.01

  

post FEF25%-75%, L/s

 

3.06 (2.94, 3.17)

2.55 (2.32, 2.78)

F(1, 538) = 15.16

<0.001

  

FEV1, ppv†

 

90.34 (88.79, 91.88)

84.20 (81.16, 87.24)

F(1, 538) = 12.46

<0.001

  

FVC, ppv†

 

93.90 (92.44, 95.35)

91.70 (88.81, 94.60)

F(1, 523) = 1.76

0.19

  

FEV1/FVC, ppv†

 

96.66 (95.81, 97.50)

91.03 (89.35, 92.70)

F(1, 523) = 34.55

<0.001

  

PEF, ppv†

 

97.24 (95.50, 98.98)

92.44 (89.02, 95.85)

F(1, 538) = 6.03

0.02

  

FEF25%-75%, ppv†

 

84.55 (81.90, 87.20)

71.28 (66.07, 76.49)

F(1, 538) = 19.79

<0.001

  

Independent variables

       

Intra-abdominal fat,%

No test

39.58 (37.26, 41.90)

39.44 (34.92, 43.96)

F(5,692) = 1.16

0.33

F(2,692) = 1.71

0.18

 

Unacceptable

38.81 (35.92, 41.70)

33.06 (27.66, 38.47)

    
 

Acceptable

39.55 (38.57, 40.52)

39.91 (37.99, 41.83)

    

Mediator variables

       

HOMA2-IR

No test

1.35 (1.09, 1.66)

2.01 (1.52, 2.52)

F(5,703) = 1.51

0.19

F(2,703) = 3.18

0.04

 

Unacceptable

1.39 (1.06, 1.71)

1.71 (1.09, 2.34)

    
 

Acceptable

1.40 (1.30, 1.59)

1.32 (1.11, 1.54)

    

SDB symptom score, range 0-12

No test

1.18 (0.63, 1.73)

1.87 (0.75, 2.98)

F(5,594) = 1.74

0.12

F(2,594) = 0.07

0.93

 

Unacceptable

1.54 (0.83, 2.25)

2.09 (0.79, 3.40)

    
 

Acceptable

0.96 (0.74, 1.18)

1.39 (0.93, 1.85)

    
  1. A description of the outcome, independent and mediator variables, and covariates by current doctor-diagnosed asthma and spirometry completion and quality, The Whyalla Intergenerational Study of Health (WISH, 2008–2009).
  2. Determination of ‘unacceptable test’ was based on either baseline and post-bronchodilator EasyOne™ system quality control (QC) grade of D or lower, or non-reproducible trials exceeding 3% variability. The analytical sample satisfied a QC grade of C or higher and reproducible trials within 3% variability. †Percentage of Predicted Value (PPV) was based on equations of Gore et al. (1995) [17].
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BMC Pulmonary Medicine

ISSN: 1471-2466

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