Abdominal adiposity and obstructive airway disease: testing insulin resistance and sleep disordered breathing mechanisms

Table 2 Associations of intra-abdominal fat percentage with lung function and asthma outcomes, and hypothesised mediators (sleep disordered breathing score and insulin resistance) in men and women, The Whyalla Intergenerational Study of Health (WISH, 2008–2009)

	Men			Women
	Coef. (bootstrap 95%CI)	P	R-squared	Coef. (bootstrap 95%CI)	P	R-squared
Current doctor-diagnosed asthma	1.002 (0.975, 1.029)	0.913		1.004 (0.983, 1.027)	0.686
Obs	214			320
log CASS	0.006 (0.000, 0.012)	0.045	0.148	0.009 (0.002, 0.016)	0.011	0.123
Obs	213			317
rev FEV1	0.045 (−0.045, 0.135)	0.328	0.077	0.005 (−0.063, 0.073)	0.892	0.026
Obs	212			313
post FEV1/FVC
L/L	0.065 (−0.028, 0.158)	0.172	0.363	0.056 (−0.002, 0.113)	0.056	0.321
PPV (Gore et al. [17])	0.090 (−0.029, 0.209)	0.138	0.229	0.066 (−0.033, 0.165)	0.194	0.129
Obs	210			300
SDB	0.055 (0.017, 0.094)	0.005	0.129	0.024 (0.002, 0.047)	0.034	0.083
Obs	178			273
HOMA2-IR	0.059 (0.048, 0.071)	<0.001	0.272	0.052 (0.038, 0.065)	<0.001	0.286
Obs	214			318

Associations of intra-abdominal fat percentage with lung function and asthma outcomes, and hypothesised mediators (sleep disordered breathing score and insulin resistance) in men and women, The Whyalla Intergenerational Study of Health (WISH, 2008–2009). FEV₁, forced expiratory volume in 1 second; FVC, forced vital capacity; IR, insulin resistance (HOMA2); SDB, sleep-disordered breathing. Covariates included in all models were age, current and past smoking, gross annual household income and number of household residents. For lung function models height and respiratory medication in the previous 24 hours were included as covariates.

ISSN: 1471-2466