Measurement of MMP-9 and -12 degraded elastin (ELM) provides unique information on lung tissue degradation

BMC Pulmonary Medicine

Table 2 Examples of cleavage kinetics of MMP-9 and -12 generated peptides identified by MS in elastin from human aorta

Amino acid no.	Identified peptides in elastin from aorta	MMP-9 cleaved (hours)						MMP-12 cleaved (hours)
Amino acid no.	Identified peptides in elastin from aorta	0	2	24	48	72	≥169	2	24	48	72	≥169
041-051	VFYPGAGLGAL					x	x
041-057	VFYPGAGLGALGGGALG		x	x	X	x	x
041-059	VFYPGAGLGALGGGALGPG		x	x	X
085-102	VTFPGALVPGGVADAAAA									x	x
141-159	VPGVGLPGVYPGGVLPGAR	x	x	x	X	x	x	x	x	x	x	x
158-164	ARFPGVG		x
229-241	GYGPGGVAGAAGK									x	x	x
230-241	YGPGGVAGAAGK		x	x	X	x		x	x		x
280-293	AGVPGVPGAIPGIG			x	X			x	x	x	x	x
281-294	GVPGVPGAIPGIGG						x	x	x	x	x	x
302-312	AAAAAAAAAAK							x
327-339	PGFGPGVVGVPGA		x	x				x	x
384-408	GARPGVGVGGIPTYGVGAGGFPGFG		x	x	X	x			x
385-392	ARPGVGVG	x	x	x

ISSN: 1471-2466