Table 1 Clinical and metabolic characteristics of patients with OSA by severity and control snorers
| Â | OSA | Â | Â | Â |
|---|---|---|---|---|
snorers | mild/moderate | severe | Â | |
|  | AHI<5 n=47 | AHI 5 – 29 n=61 | AHI≥30 n=30 | P |
Age | 51.3±11.7 | 53.2±11.7 | 56.6±9.8 | NS |
Males (%) | 66.0 | 70.5 | 83.3 | NS |
AHI (events/h) | 1.2±1.4 | 14.6±8.0 | 42.8±14.2 | <0.001 |
Average SaO ² | 95,0±1,4 | 93,6±2,2 | 92,6±2,5 | <0,01 |
Body Mass Index (kg/m2) | 29,3±3,9 | 30,5±4,5 | 32,8±5,1 | <0,01 |
Waist circumference (cm) | 102,5±11,1 | 105,8±12,1 | 113,6±12,1 | <0,001 |
Hip circumference (cm) | 106,5±8,5 | 109,9±9,1 | 116,9±11,7 | <0,001 |
Blood glucose (mg/dl) | 103.1±24.5 | 107.5±41.5 | 107.1±28.1 | 0.428 |
Insulin (μU/mL) | 14.0±6.7 | 19.2±19.3 | 24.4±22.4 | <0.05 |
HOMA-IR | 3.6±1.9 | 5.8±6.8 | 8.4±11.1 | <0.01 |
Total cholesterol (mg/dl) | 210.4±41.4 | 201.4±38.7 | 207.9±39.9 | NS |
LDL-cholesterol (mg/dl) | 137.7±35.2 | 128.0±33.7 | 128.8±33.3 | NS |
HDL-cholesterol (mg/dl) | 46.8±11.5 | 46.0±11.5 | 45.8±9.9 | NS |
Triglycerides (mg/dl) | 131.1±65.8 | 136.1±80.7 | 167.5±134.0 | NS |
Urinary 8-iso-PGF2α (pg/mg creatinine) | 284.0±77,3 | 289.5±77,0 | 337.6±74.5 | <0.001 |
sNOX2-dp (pg/ml) | 26.2±8,2 | 26.3±7.5 | 28,8±8.0 | NS |
Serum NOx (uM/ml) | 27.1±14.6 | 27.0±12,5 | 23,6±16.0 | NS |
FMD% | 6.2±3.2 | 7.2±4.6 | 4.9±2.7 | <0.05 |