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Table 2 Association of ACE gene D/I polymorphism with variables used as markers of severity of CF, patients followed at the pediatric center in UNICAMP distributed by CFTR gene mutation identified divided into cohorts

From: The ACE gene D/I polymorphism as a modulator of severity of cystic fibrosis

Variable Without taking CFTRmutation into account No identified mutation One identified mutation Two identified mutation
E p E p E p E p
Patients age W:0.791 0.374 W:3x10-5 0.995 W:2.969 0.085 W:0.001 0.984
Onset of clinical manifestations W:0.116 0.733 W:0.162 0.687 W:4.29 0.038 W:0.937 0.333
Diagnostic W:0.11 0.74 W:0.047 0.83 W:0.099 0.753 W:0.087 0.768
Onset of digestive symptons W:1.494 0.221 W:0.148 0.7 W:0.297 0.586 W:0.979 0.322
Onset of lung symptons W:0.021 0.885 W:0.039 0.843 W:0.401 0.526 W:1.302 0.31
BMI W:1.169 0.28 W:0.687 0.407 W:0.436 0.509 W:2.498 0.114
Nasal poliposys W:0.62 0.431 W:0.984 0.321 W:0.419 0.517 W:1.26 0.262
Diabetes W:0.358 0.55 W:0.016 0.901 W:0.174 0.676 W:0.184 0.668
Osteoporosis W:0.877 0.349 W:1.056 0.0304 W:0.561 0.454 W:0.083 0.773
Pancreatic insuficience W:1.6 0.206 W:0.693 0.406 W:1.063 0.302 W:0.182 0.669
Meconium ileus W-0.252 0.616 W:3.813 0.051 W:1.109 0.292 W:1.498 0.221
SaO2 F:2.131 0.142 F:0.022 0.884 F:1.868 0.178 F:1.344 0.25
Scores Bhalla F:6.526 0.012 F:0.2 0.689 F:4.942 0.032 F:4.013 0.049
Kanga F:1.3 0.256 F:0.486 0.492 F:0.027 0.871 F:3.765 0.057
SK F:2.361 0.127 F:0.286 0.597 F:1.042 0.312 F:1.243 0.269
FVC F:0.139 0.71 F:0.829 0.37 F:0.918 0.345 F:0.93 0.339
FEV1 F:0.785 0.377 F:0.622 0.436 F:0.907 0.348 F:2.797 0.099
FEV1/FVC F:0.891 0.347 F:0.005 0.943 F:2.212 0.146 F:0.156 0.694
FEF25-75% F:0.42 0.518 F:0.112 0.735 F:0.02 0.887 F:1.048 0.31
1a P. aeruginosa isolated W:0.962 0.327 W:0.702 0.402 W:0.16 0.69 W:0.099 0.753
Isolated Bacteria PAM W:0.92 0.338 W:0.141 0.708 W:2.016 0.156 W:0.165 0.684
PANM W:1.21 0.272 W:1.149 0.284 W:0.987 0.753 W:0.262 0.609
AX W:3.2 0.074 W:0.038 0.845 W:0.642 0.423 W:2.911 0.088
BC W:4.290 0.038 W:0.1 0.753 W:3.681 0.055 W:0.341 0.559
SA W:0.209 0.65 W:1.151 0.283 W:0.191 0.662 W:1.102 0.294
  1. Analysis by linear regression (F) and logistic regression (W) test . Values below of 0.05 for p denote a clinical correlation between variables. E - Statistical,% - percentage, SaO2 - transcutaneous oxygen saturation, FEV1 – forced expiratory volume in 1 second, FVC – forced expiratory capacity, FEV1/FVC – ratio between two variables, forced FEF25-75, SC - expiratory flow at 25-75% of the pulmonary volume, SK - Shwachman-Kulczycki, PAM – P. aeruginosa mucoid, PAM – P. aeruginosa non mucoid, AX – A. xylosoxidans, BC – B. cepacia, SA – S. aureus, BMI – body mass index, CF - cystic fibrosis, ACE – angiotensin converting enzyme. No identified mutation (44 patients) – patients without of identified mutation in classes I, II or III. One identified mutation (51 patients) – patient with one identified mutation in class I, II, or III. Two identified mutation (85 patients) – patient with two mutations in class I, II and/or III. Others identified mutations as class IV (P205S e R334W) was included in the statistical analysis in the not identified mutation subgroup, to minimize the associated factor with the mutation classes in the CFTR gene.