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Table 1 Patient characteristics and outcome of unmatched ALI patients

From: Early intravenous unfractionated heparin and outcome in acute lung injury and acute respiratory distress syndrome – a retrospective propensity matched cohort study

  No Heparin n = 559 Heparin n = 164 pvalue
Age, mean (SD) 59 (17) 63 (14) 0.003
Male,% (n) 70 (389) 63 (103) 0.10
APACHE II score, mean (SD) 17.8 (6.9) 19.8 (6.5) 0.001
Medical patients,% (n) 60 (334) 71 (117) 0.007
Surgery elective,% (n) 23 (128) 19 (31) 0.28
Surgery emergency,% (n) 17 (97) 7 (16) 0.02
Medical condition
Multiple Trauma,% (n) 8 (43) 2 (3) 0.007
Sepsis,% (n) 21 (115) 18 (29) 0.42
Diabetes,% (n) 14 (81) 16 (27) 0.53
Liver Failure,% (n) 3 (14) 2 (4) 0.96
Hematological malignancy,% (n) 6 (35) 2 (3) 0.03
Aspiration,% (n) 5 (26) 4 (6) 0.59
Pancreatitis,% (n) 2 (12) 2 (4) 0.82
Pneumonia,% (n) 23 (129) 10 (17) < 0.001
COPD 11 (62) 14 (23) 0.31
Auto immune disease,% (n) 6 (34) 9 (15) 0.17
Previous Myocardial infarction,% (n) 13 (72) 40 (66) < 0.001
Immune Compromised,% (n) 11 (61) 6 (10) 0.07
Massive Transfusion,% (n) 14 (78) 12 (19) 0.43
Life support measures
Respiratory failure (MV) ,% (n) 93 (519) 95 (156) 0.42
Cardiovascular failure (MI) ,% (n) 13 (72) 40 (66) <0.001
Co interventions
Activated Protein C,% (n) 4 (24) 1 (1) 0.02
Stress dose steroids,% (n) 42 (233) 46 (76) 0.29
Protective mechanical ventilation (<8 ml/kg) ,% (n) 54 (304) 55 (91) 0.29
Restrictive fluid strategy (net fluid balance first 7 days ≤ 0 ml) ,% (n) 36 (203) 35 (58) 0.82
Outcome
28 days mortality,% (n) 24 (134) 30 (50) 0.09
90 days mortality,% (n) 32 (181) 39 (64) 0.11
ICU-stay, median (IQR) 7 (4–13) 7 (4–13) 0.59
Hospital-stay, median (IQR) 20 (11–38) 18 (8–37) 0.13
  1. APACHE = Acute Physiology and Chronic Health Evaluation, COPD = chronic obstructive pulmonary disease, IQR = interquartile range, MI = myocardial infarction, MV = mechanical ventilation, SD = standard deviation.