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Table 2 Association of polymorphisms in ADRB2 gene with spirometry of Cystic Fibrosis patients 1

From: Polymorphisms in ADRB2 gene can modulate the response to bronchodilators and the severity of cystic fibrosis

Variable

Arg16Gly

Gln27Glu

 

Arg/Arg

Arg/Gly

Gly/Gly

F

p

Gln/Gln

Gln/Glu

Glu/Glu

F

p

FVC (%)

23 (82.04 ± 4.48)

54(79.30 ± 3.21)

44(75.05 ± 3.43)

3.25

0.08

63(77.9 ± 2.92)

48(79 ± 3.37)

10(77.1 ± 6.48)

0.02

0.90

FEV1 (%)

23(72 ± 5.57)

53(72.57 ± 3.47)

44(66.64 ± 4.10)

6.80

0.01

62(70.34 ± 3.49)

48(70.75 ± 3.63)

10(67.70 ± 8)

0.45

0.50

FEV1/FVC

23(82 ± 4.27)

52(84.79 ± 1.82)

44(83.33 ± 2.44)

1.12

0.29

62(85.32 ± 1.9)

47(82.21 ± 2.48)

10(82.20 ± 4.96)

0.17

0.68

FEF25-75%

23(58.17 ± 7.22)

53(59.91 ± 4.48)

44(56.98 ± 5.75)

5.82

0.02

62(61.34 ± 4.64)

48(55.88 ± 4.84)

10(53.50 ± 9.99)

1.23

0.27

  1. % - Percentage; FVC - forced vital capacity; FEV - forced expiratory volume; FEF25-75% - forced expiratory flow between 27-75% of the FVC. 1. Continuous variables expressed as number of patients (mean ± SD (range). Statistical analysis conducted by analysis of variance (ANOVA) through (in bold) statistically significant values with less than 0.05.