Table 1 Demographic and baseline clinical characteristics of patients able to exercise reliably
From: Assessment of measurement properties of peak VO2in children with pulmonary arterial hypertension
Placebo (N = 30) | Sildenafil (N = 85) | |
|---|---|---|
Female sex, n (%) | 19 (63) | 53 (62) |
Age, y, n (%) | ||
5–12 | 18 (60) | 39 (46) |
13–17 | 12 (40) | 46 (54) |
Race, n (%) | ||
White | 8 (27) | 27 (32) |
Black | 2 (7) | 1 (1) |
Asian | 4 (13) | 20 (24) |
Other | 16 (53) | 37 (44) |
Weight, kg, mean (range) | 37 (20–60) | 40 (15–106) |
BMI, kg/m2, mean (SD) | 18 (3) | 18 (4) |
Peak VO2, mL/kg/min, mean (SD) | 20.0 (3.7) | 17.7 (4.2) |
WHO functional class, n (%) | ||
I | 10 (33) | 19 (22) |
II | 17 (57) | 44 (52) |
III | 3 (10) | 20 (24) |
Missing | 0 | 2 (2) |
Etiology, n (%) | ||
IPAH/HPAH | 10 (33) | 31 (36) |
Surgical repair* | 7 (23) | 22 (26) |
Congenital systemic-to-pulmonary shunt (SaO2 ≥88% at rest) | 12 (40) | 30 (35) |
Post-repair D-transposition of great arteries | 1 (3) | 2 (2) |
Mean pulmonary artery pressure, mmHg, mean (SD) | 58.7 (19.9) | 68.4 (23.1) |
Cardiac index, L/min/m2, mean (SD) | 3.4 (1.4) | 3.0 (1.1) |
Pulmonary vascular resistance index, dyn·s/cm5/m2, mean (SD) | 1299 (775) | 1871 (1232) |
Mean pulmonary capillary wedge pressure, mmHg, mean (SD) | 10.0 (3.6) | 9.7 (4.5) |
Mean right atrial pressure, mmHg, mean (SD) | 8.3 (4.5) | 8.4 (4.9) |