The modified Medical Research Council scale for the assessment of dyspnea in daily living in obesity: a pilot study

Table 5 Comparisons of patients with mMRC = 0 and patients with mMRC ≥ 1 concerning clinical characteristics, lung function and biological parameters

	MRC = 0 (n = 7)	MRC ≥ 1 (n = 38)
Demographic characteristics
Age	50 ± 10	51 ± 11
Sex (M/F)	4/3	13/25
BMI (kg/m ² )	36 ± 5	44 ± 9*
Smoking history
Pack-years	10 ± 16	10 ± 17
PFTs
FEV₁,% pred	101 ± 16	86 ± 17*
VC,% pred	103 ± 15	90 ± 20
FEV₁/VC	0.78 ± 0.05	0.77 ± 0.11
FRC,% pred	100 ± 16	91 ± 25
ERV,% pred	91 ± 32	50 ± 31**
TLC,% pred	101 ± 11	97 ± 17
DLCO,% pred	86 ± 18	83 ± 19
Arterial blood gases
PaO2 (mmHg)	99 ± 24	88 ± 14
PaCO2 (mmHg)	39 ± 4	39 ± 4
6-minute walk test
6-minute walk distance (m)	524 ± 72	401 ± 107**
SpO2 at rest (%)	98 ± 2	97 ± 2
SpO2 after exertion (%)	94 ± 2	96 ± 2
Borg score at res	0.1 ± 0.4	1.1 ± 1.6
Borg score after 6MWT	3.9 ± 3	5.7 ± 2.1
Biological parameters
Hemoglobin (g/dL)	14.8 ± 1,3	13.7 ± 1,5*
NT pro-BNP (pg/mL)	97 ± 199	121 ± 301
CRP (mg/L)	5 ± 4,9	9.1 ± 7,4
Triglyceride (mmol/L)	1.9 ± 0,9	1.5 ± 0,8
Total cholesterol (mmol/L)	5.4 ± 1	4.7 ± 1
Fasting glucose (mmol/L)	5.3 ± 0,8	7.8 ± 3,3
Hba1c (%)	5.7 ± 0,6	6.8 ± 1,6

Data are expressed as number (%) or mean ± SD; *p value < 0.05, **p value < 0.01.
FEV₁: expiratory volume in one second, pred: predicted value, VC: vital capacity, FRC: functional residual capacity, ERV: expiratory reserve volume, TLC: total lung capacity, DLCO: carbon monoxide diffusing capacity of the lung, NT pro-BNP: N-terminal pro brain natriuretic peptide, CRP: serum C reactive protein, HbA1c: glycated hemoglobin.
Normal biological parameters values were based on the normal values for our laboratory: fasting glucose: 3.3 to 6.1 mmol/L; HbA1c: 4 to 6%; total cholesterol: 3 to 5.2 mmol/L; triglycerides: 0.3 to 1.7 mmol/L; NT-pro BNP < 300 pg/mL; CRP < 10 mg/L. Anemia was defined as hemoglobin level < 13 g/dL in men and 12 g/dL in women.

ISSN: 1471-2466