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Table 1 GINA recommended treatment steps for 5 to 18 year olds

From: A systematic review with attempted network meta-analysis of asthma therapy recommended for five to eighteen year olds in GINA steps three and four

Step 1 Step 2 Step 3 (Select one) Step 4 (Add one or more)
SABA Low dose ICS A. Medium-or high dose ICS A. Medium-or high dose ICS + LABA
   B. Low dose ICS + LABA B. LTRA
   C. Low dose ICS + LTRA C. Theophylline
   D. Low dose ICS + Theophylline  
  1. SABA = rapidly acting ß2-agonists; ICS = Inhaled Corticosteroids; LABA = Long–acting β2-adrenoceptor agonists; LTRA = Leukotriene modifier.