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Table 4 Reported significant differences between intervention groups per trial

From: A systematic review with attempted network meta-analysis of asthma therapy recommended for five to eighteen year olds in GINA steps three and four

Study 3A-3B 3B-4A
Outcome Gappa[32] Differences between groups (95%CI) Bisgaard[6] Differences between groups (p) De Blic[36] Differences between groups (95%CI; p) Tal[29] Differences between groups (95%CI) Morice[30] Differences between groups (95%CI; p) Pohunek[31] Differences between groups (p)
Number of exacerbations n.a. n.d. n.d. n.a. n.a. n.a.
Level of control p=0.02a 9.8(0.047)b n.d. n.d. n.d. n.d.
Reliever medication use/reliever free daysc 8.7(1.2-16.3) n.d. 1.4(0.0-3.4; 0.025) n.d. n.d. n.d.
Symptom score (day&night) n.d. 0.27(0.024) n.a. n.d. n.d. n.d.
nighttime awakening n.a. n.d. n.d. n.d. n.d. n.d.
Quality of life n.a. n.a. n.a. n.a. n.d. n.d.
Lung function (FEV1) n.d. n.d. n.d. 3.75(1.1-6.4)d n.a. 0.08(<0.01)e & 0.06(<0.001)e
Hyperresponsiveness (PC20-FEV1) n.a. n.a. n.a. n.a. n.a. n.a.
morning PEF 6.1(1.8-10.4)d n.d. 7.6(1.7-13.5)e 3.77(1.84-5.7)d 9.5(4.2-14.9; <0.001)e & 10.3(5.0-15.6; <0.001)e,f 15(<0.001)e & 6(<0.001)e,f
  1. a nr of weeks with successful asthma control.
  2. b asthma-control days (%).
  3. c Percentage of days without rescue medication.
  4. d % of predicted.
  5. e liter.
  6. f For some studies 2 results are presented because three groups were compared in the trial.
  7. n.a. = not available.
  8. n.d. = no statistically significant differences.