A systematic review with attempted network meta-analysis of asthma therapy recommended for five to eighteen year olds in GINA steps three and four

Table 4 Reported significant differences between intervention groups per trial

Study	3A-3B			3B-4A
Outcome	Gappa[32] Differences between groups (95%CI)	Bisgaard[6] Differences between groups (p)	De Blic[36] Differences between groups (95%CI; p)	Tal[29] Differences between groups (95%CI)	Morice[30] Differences between groups (95%CI; p)	Pohunek[31] Differences between groups (p)
Number of exacerbations	n.a.	n.d.	n.d.	n.a.	n.a.	n.a.
Level of control	p=0.02^a	9.8(0.047)^b	n.d.	n.d.	n.d.	n.d.
Reliever medication use/reliever free days^c	8.7(1.2-16.3)	n.d.	1.4(0.0-3.4; 0.025)	n.d.	n.d.	n.d.
Symptom score (day&night)	n.d.	0.27(0.024)	n.a.	n.d.	n.d.	n.d.
nighttime awakening	n.a.	n.d.	n.d.	n.d.	n.d.	n.d.
Quality of life	n.a.	n.a.	n.a.	n.a.	n.d.	n.d.
Lung function (FEV₁)	n.d.	n.d.	n.d.	3.75(1.1-6.4)^d	n.a.	0.08(<0.01)^e & 0.06(<0.001)^e
Hyperresponsiveness (PC₂₀-FEV₁)	n.a.	n.a.	n.a.	n.a.	n.a.	n.a.
morning PEF	6.1(1.8-10.4)^d	n.d.	7.6(1.7-13.5)^e	3.77(1.84-5.7)^d	9.5(4.2-14.9; <0.001)^e & 10.3(5.0-15.6; <0.001)^e,f	15(<0.001)^e & 6(<0.001)^e,f

^a nr of weeks with successful asthma control.
^b asthma-control days (%).
^c Percentage of days without rescue medication.
^d % of predicted.
^e liter.
^f For some studies 2 results are presented because three groups were compared in the trial.
n.a. = not available.
n.d. = no statistically significant differences.

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