Figure 3

Sputum neutrophils (left) and the sum of sputum monocytes and small macrophages (right). Individual data and mean values of percent sputum leukocytes are displayed. BL: baseline, LPS 1: first LPS challenge, LPS 2: second LPS challenge at least 4 weeks after LPS 1, LPS Tx: third LPS challenge at least 4 weeks after LPS 2 and after 5 days of treatment with Roflumilast (500 μg /day). For statistical details please refer to Table 2. ** p < 0.01, *** p < 0.001 compared with baseline; # p < 0.05 compared with LPS 1.