Table 1 Timeline of the clinical course
Date | Clinical course | Therapy |
|---|---|---|
November 2004 | Diagnosis of usual interstitial pneumonia (UIP) | |
August 2009 | Double lung transplantation, complicated postoperative course | |
November 2009 | Rehabilitation treatment | |
December 2009 - January 2010 | Persistent cough | Admission to general hospital |
3.1.2010 | Aggravation of general/ respiratory condition | Admission to intensive care unit |
Respiratory insufficiency | Intubation | |
5.1.2010 | Nasotracheal secretion positive for viral influenza A/H1N1 RNA (working diagnosis: H1N1 pneumonia with bacterial superinfection) | Meropenem, clarithromycin and oseltamivir |
7.1.2010 | Detection of viral influenza A/H1N1 RNA by real-time PCR (bronchoscopy) | |
Detection of mutation causing resistence against oseltamivir | Switch from oseltamivir to zanamivir | |
Acute renal failure | Continuous venous-venous hemofiltration | |
8.1.2010 | Respiratory insufficiency | Extracorporeal interventional lung assist implantation |
11.1.2010 | Rapidly progressive respiratory failure | Death |