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Table 4 Spirometry and vagal function tests: baseline and following saline and acid perfusion (all asthmatics; n=40)

From: Response of the airways and autonomic nervous system to acid perfusion of the esophagus in patients with asthma: a laboratory study

Parameter Baseline After saline perfusion After acid perfusion P value*
Saline versus acid perfusion
Spirometry (L/min)     
FVC 3.2 ± 0.10 3.2 ± 0.10 3.2 ± 0.10 0.084
FEV1 2.7 ± 0.08 2.7 ± 0.08 2.6 ± 0.07 0.001
PEFR 4.2 ± 0.14 4.1 ± 0.15 4.0 ± 0.13 0.023
Vagal function tests     
Valsalva ratio 1.26 ± 0.04 1.23 ± 0.03 1.31 ± 0.04 0.011
Heart rate ratio on standing from supine position 1.16 ± 0.02 1.14 ± 0.02 1.12 ± 0.02 0.612
Heart rate difference on deep breathing 23.09 ± 1.16 23.6 ± 1.16 26.0 ± 1.40 0.004
  1. * Repeated measures analysis; All values as mean ± SE.
  2. FVC Forced Vital Capacity, FEV 1 Forced Expiratory Volume in 1st Second, PEFR Peak Expiratory Flow Rate.