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Table 5 Pulmonary and vagal function tests of asthmatics (categorized according to reflux (on pH monitoring) and GERD symptom score following distal esophageal acid or saline perfusion

From: Response of the airways and autonomic nervous system to acid perfusion of the esophagus in patients with asthma: a laboratory study

 

Asthmatics with reflux and a negative GERD symptom score( n= 10)

Asthmatics with reflux and a positive GERD symptom score( n= 10)

Asthmatics without reflux and a negative GERD symptom score( n= 10)

Asthmatics without reflux and a positive GERD symptom score (n=10)

 

Saline

Acid

Saline

Acid

Saline

Acid

Saline

Acid

FVC (L)

3.0 ± 0.2

3.0 ± 0.2

3.0 ± 0.2

3.0 ± 0.2

3.4 ± 0.2

3.3 ± 0.2

3.1 ± 0.1

3.1 ± 0.1

FEV1 (L)

2.6 ± 0.2

2.4 ± 0.1

2.6 ± 0.2

2.4 ± 0.2

2.8 ± 0.2

2.8 ± 0.1

2.6 ± 0.1

2.6 ± 0.1

PEFR (L/min)

4.1 ± 0.2

4.1 ± 0.2

4.2 ± 0.2

4.1 ± 0.2

4.1 ± 0.3

3.9 ± 0.2

3.8 ± 0.2

3.7 ± 0.2

HR Ratio

1.1 ± 0.02

1.1 ± 0.03

1.1 ± 0.02

1.1 ± 0.03

1.2 ± 0.06

1.2 ± 0.05

1.0 ± 0.02

1.0 ± 0.03

HR diff

23.7 ± 2.3

26.0 ± 2.8

23.7 ± 2.4

26.0 ± 2.8

22.0 ± 2.6

25.2 ± 3.2

24.8 ± 2.8

27.0 ± 3.1

VR

1.2 ± 0.06

1.4 ± 0.1

1.2 ± 0.06

1.4 ± 0.09

1.2 ± 0.1

1.3 ± 0.1

1.3 ± 0.05

1.4 ± 0.09

  1. All values as mean ± SE.
  2. FVC Forced Vital Capacity, FEV 1 Forced Expiratory Volume in 1st second, PEFR Peak Expiratory Flow Rate.
  3. HR Ratio Heart rate ratio (30th beat/ 15th beat) on standing from supine position, HR Diff Heart rate difference between inspiration and expiration during deep breathing at 6 cycles per minute, VR ratio of maximum heart rate during the valsalva maneuver to the maximum heart rate around the 20th beat after stopping the maneuver.