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Table 3 Association between genetic polymorphisms, emphysema and pulmonary function

From: Association of genes of protease-antiprotease balance pathway to lung function and emphysema subtypes

Phenotype

Gene

Polymorphism

β*

p-value

Emphysema

    

  All

TIMP2

rs2277698 (G/A)

0.071

0.022

  Centrilobular

TGFB1

rs2241718 (G/A)

−0.071

0.022

 

MMP9

rs3918242 (C/T)

−0.082

0.008

  Paraseptal

TNF

rs1800629 (G/A)

0.075

0.017

 

TIMP2

rs2277698 (G/A)

0.081

0.010

FEV 1 /FVC ratio

TIMP2

rs2277698 (G/A)

−0.066

0.035

MEF50

TIMP2

rs2277698 (G/A)

−0.084

0.008

  1. FEV1/FVC ratio = FEV1/FVC x 100; MEF50 = maximal expiratory flow at 50% of forced vital capacity, % predicted; Covariates used in the analysis: sex, age, PYs, and years of asbestos exposure for emphysema scores; pack-years and years of asbestos exposure for MEF50.
  2. *Standardized coefficient β.
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BMC Pulmonary Medicine

ISSN: 1471-2466

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