|
Phenotype
|
Gene
|
Polymorphism
|
β*
|
p-value
|
|---|
|
Emphysema
| | | | |
|
All
|
TIMP2
|
rs2277698 (G/A)
|
0.071
|
0.022
|
|
Centrilobular
|
TGFB1
|
rs2241718 (G/A)
|
−0.071
|
0.022
|
| |
MMP9
|
rs3918242 (C/T)
|
−0.082
|
0.008
|
|
Paraseptal
|
TNF
|
rs1800629 (G/A)
|
0.075
|
0.017
|
| |
TIMP2
|
rs2277698 (G/A)
|
0.081
|
0.010
|
|
FEV
1
/FVC ratio
|
TIMP2
|
rs2277698 (G/A)
|
−0.066
|
0.035
|
|
MEF50
|
TIMP2
|
rs2277698 (G/A)
|
−0.084
|
0.008
|
- FEV1/FVC ratio = FEV1/FVC x 100; MEF50 = maximal expiratory flow at 50% of forced vital capacity, % predicted; Covariates used in the analysis: sex, age, PYs, and years of asbestos exposure for emphysema scores; pack-years and years of asbestos exposure for MEF50.
-
*Standardized coefficient β.
