Association of genes of protease-antiprotease balance pathway to lung function and emphysema subtypes

BMC Pulmonary Medicine

Table 6 Distribution of TGFB1 haplotypes according to the existence and severity of centrilobular changes

Haplotype^*	No radiologic changes	Radiologic changes	OR (95% CI)^‡	Subnormal^§ changes	OR (95% CI)^‡	Pathological^# changes	OR (95% CI)^‡
Haplotype^*	n (%)^†	n (%)^†		n (%)^†		n (%)^†
GT	834 (57.7)	283 (62.1)	1.0	125 (59.5)	1.0	158 (64.2)	1.0
GC	398 (27.5)	119 (26.1)	0.88 (0.68-1.14)	52 (24.8)	0.91 (0.64-1.30)	67 (27.2)	0.90 (0.65-1.26)
AT	187 (12.9)	50 (11.0)	0.79 (0.55-1.13)	30 (14.3)	1.10 (0.71-1.72)	20 (8.1)	0.55 (0.33-0.93)
AC	27 (1.9)	4 (0.9)	0.44 (0.15-1.32)	3 (1.4)	0.72 (0.21-2.44)	1 (0.4)	0.22 (0.03-1.70)

^*Composed of rs1800469 and rs1800470 SNPs.
^†Data are presented as number of chromosomes (%).
^‡Adjusted for age, sex, pack-years and years of asbestos exposure.
^§The changes were considered as subnormal if the emphysema subtype score was <1 (< 2 in emphysema sum score).
^#The changes were considered as pathological if the emphysema subtype score was ≥1 (≥ 2 in emphysema sum score).

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