Skip to main content

Table 6 Distribution of TGFB1 haplotypes according to the existence and severity of centrilobular changes

From: Association of genes of protease-antiprotease balance pathway to lung function and emphysema subtypes

Haplotype* No radiologic changes Radiologic changes OR (95% CI) Subnormal§ changes OR (95% CI) Pathological# changes OR (95% CI)
n (%) n (%)   n (%)   n (%)  
GT 834 (57.7) 283 (62.1) 1.0 125 (59.5) 1.0 158 (64.2) 1.0
GC 398 (27.5) 119 (26.1) 0.88 (0.68-1.14) 52 (24.8) 0.91 (0.64-1.30) 67 (27.2) 0.90 (0.65-1.26)
AT 187 (12.9) 50 (11.0) 0.79 (0.55-1.13) 30 (14.3) 1.10 (0.71-1.72) 20 (8.1) 0.55 (0.33-0.93)
AC 27 (1.9) 4 (0.9) 0.44 (0.15-1.32) 3 (1.4) 0.72 (0.21-2.44) 1 (0.4) 0.22 (0.03-1.70)
  1. *Composed of rs1800469 and rs1800470 SNPs.
  2. Data are presented as number of chromosomes (%).
  3. Adjusted for age, sex, pack-years and years of asbestos exposure.
  4. §The changes were considered as subnormal if the emphysema subtype score was <1 (< 2 in emphysema sum score).
  5. #The changes were considered as pathological if the emphysema subtype score was ≥1 (≥ 2 in emphysema sum score).