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Table 3 Changes in iso-time parameters during incremental exercise after pulmonary rehabilitation with ghrelin or placebo

From: Effects of Ghrelin Treatment on Exercise Capacity in Underweight COPD Patients: a substudy of a multicenter, randomized, double-blind, placebo-controlled trial of ghrelin treatment

  Ghrelin, n = 10 Placebo, n = 10 Treatment effect (95% CI; p value)
  Pre-treatment Mean D. Pre-treatment Mean D.  
V o 2 mL / kg / min 13.2 (3.7) 0.5 (1.8) 13.4 (3.2) -0.8 (1.1) 1.2 (-0.2 to 2.6; 0.085)
Dyspnea (Borg) 7.2 (1.5) -2.0 (2.6)* 7.0 (1.7) -2.7 (3.2)* 0.7 (-2.1 to 3.4; 0.606)
Leg discomfort (Borg) 5.4 (2.7) -1.9 (2.9) 6.2 (2.6) -3.0 (2.9)* 1.1 (-1.6 to 3.9; 0.399)
VT (L) 0.97 (0.16) 0.10 (0.08)** 1.06 (0.12) 0.09 (0.24) 0.01 (-0.15 to 0.18; 0.876)
f (breaths/min) 34 (7) -4 (6)* 28 (5) -3 (8) -1 (-8 to 5; 0.658)
V E L / min 31.8 (6.1) -0.4 (4.6) 29.2 (6.5) -1.6 (3.6) 1.2 (-2.6 to 5.1; 0.510)
VD/VT 0.39 (0.06) -0.03 (0.04)* 0.36 (0.05) 0.01 (0.04) -0.04 (-0.08 to -0.00; 0.048)
V E / V o 2 52.5 (12.7) -3.3 (3.6)* 47.9 (7.2) 0.2 (4.9) -3.5 (-7.6 to 0.5; 0.086)
V E / V c o 2 51.1 (13.7) -2.7 (5.3) 45.2 (7.5) 0.9 (5.2) -3.6 (-8.6 to 1.4; 0.149)
Pao2 (mmHg) 64.5 (16.0) 1.0 (5.4) 66.2 (11.8) -1.1 (4.8) 2.1 (-2.7 to 7.0; 0.361)
Paco2 (mmHg) 42.6 (6.9) -1.1 (2.4) 42.4 (4.2) 0.0 (3.1) -1.2 (-3.8 to 1.4; 0.359)
HR (beats/min) 118 (14) -2 (9) 113 (13) 2 (6) -4 (-11 to 4; 0.290)
V o 2 / HR mL / beats 5.4 (1.5) 0.2 (0.8) 5.5 (1.1) -0.3 (0.4)* 0.5 (-0.1 to 1.1; 0.093)
Plasma LT (mg/dL) 32.1 (11.8) -0.3 (8.3) 34.9 (14.6) -3.5 (7.9) 3.2 (-4.4 to 10.8; 0.920)
Plasma NE (ng/mL) 2.44 (1.71) -0.37 (1.40) 2.64 (1.81) -0.77 (1.06)* 0.40 (-0.77 to 1.56; 0.426)
  1. Data are presented as means (SD) unless otherwise indicated. D, Difference from pre-treatment; f, breathing frequency; HR, Heart Rate; LT, Plasma Lactate level; NE, Plasma Norepinephrine level; Paco 2 , Arterial carbon dioxide tension; Pao 2 , Arterial oxygen tension; Treatment effect, Mean difference (ghrelin minus placebo); V D /V T , Physiologic dead space/tidal volume ratio; V E Minute ventilation, V o 2 Oxygen uptake; V T , Tidal volume. * p < 0.05, ** p < 0.01: change between pre-treatment and post-treatment (within-group difference) by paired t-test. change between pre-treatment and post-treatment (treatment effect) by unpaired t-test.