Table 3 Changes in iso-time parameters during incremental exercise after pulmonary rehabilitation with ghrelin or placebo

$\stackrel{•}{V}{o}_2\left(\mathrm{mL}/\mathrm{kg}/\min \right)$

13.2 (3.7)

0.5 (1.8)

13.4 (3.2)

-0.8 (1.1)

1.2 (-0.2 to 2.6; 0.085)

Dyspnea (Borg)

7.2 (1.5)

-2.0 (2.6)^*

7.0 (1.7)

-2.7 (3.2)^*

0.7 (-2.1 to 3.4; 0.606)

Leg discomfort (Borg)

5.4 (2.7)

-1.9 (2.9)

6.2 (2.6)

-3.0 (2.9)^*

1.1 (-1.6 to 3.9; 0.399)

V_T (L)

0.97 (0.16)

0.10 (0.08)^**

1.06 (0.12)

0.09 (0.24)

0.01 (-0.15 to 0.18; 0.876)

f (breaths/min)

34 (7)

-4 (6)^*

28 (5)

-3 (8)

-1 (-8 to 5; 0.658)

$\stackrel{•}{V}E\left(\mathrm{L}/\min \right)$

31.8 (6.1)

-0.4 (4.6)

29.2 (6.5)

-1.6 (3.6)

1.2 (-2.6 to 5.1; 0.510)

V_D/V_T

0.39 (0.06)

-0.03 (0.04)^*

0.36 (0.05)

0.01 (0.04)

-0.04 (-0.08 to -0.00; 0.048)

$\stackrel{•}{V}E/\stackrel{•}{V}{o}_2$

52.5 (12.7)

-3.3 (3.6)^*

47.9 (7.2)

0.2 (4.9)

-3.5 (-7.6 to 0.5; 0.086)

$\stackrel{•}{V}E\stackrel{•}{/V}c{o}_2$

51.1 (13.7)

-2.7 (5.3)

45.2 (7.5)

0.9 (5.2)

-3.6 (-8.6 to 1.4; 0.149)

Pao₂ (mmHg)

64.5 (16.0)

1.0 (5.4)

66.2 (11.8)

-1.1 (4.8)

2.1 (-2.7 to 7.0; 0.361)

Paco₂ (mmHg)

42.6 (6.9)

-1.1 (2.4)

42.4 (4.2)

0.0 (3.1)

-1.2 (-3.8 to 1.4; 0.359)

HR (beats/min)

118 (14)

-2 (9)

113 (13)

2 (6)

-4 (-11 to 4; 0.290)

$\stackrel{•}{V}{o}_2/\mathit{HR}\left(\mathrm{mL}/\mathrm{beats}\right)$

5.4 (1.5)

0.2 (0.8)

5.5 (1.1)

-0.3 (0.4)^*

0.5 (-0.1 to 1.1; 0.093)

Plasma LT (mg/dL)

32.1 (11.8)

-0.3 (8.3)

34.9 (14.6)

-3.5 (7.9)

3.2 (-4.4 to 10.8; 0.920)

Plasma NE (ng/mL)

2.44 (1.71)

-0.37 (1.40)

2.64 (1.81)

-0.77 (1.06)^*

0.40 (-0.77 to 1.56; 0.426)